A lichen substance as an antiproliferative compound against HL-60 human leukemia cells: 16-O-acetyl-leucotylic acid isolated from Myelochroa aurulenta

The lichen substance, 16-O-acetyl-leucotylic acid (1), was isolated from an acetone extract of Myelochroa aurulenta and found to exhibit antiproliferative activity against HL-60 human leukemia cells. This is the first report on its anti-leukemia activity (EC 50 =21 μM) which is greater than that of...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2009-11, Vol.73 (11), p.2525-2527
Hauptverfasser:	Tokiwano, T., Akita Prefectural Univ. (Japan), Satoh, H, Obara, T, Hirota, H, Yoshizawa, Y, Yamamoto, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	16-O-acetyl-leucotylic acid Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology antiproliferation Ascomycota - chemistry Biological and medical sciences CARCINOMA CARCINOME Cell Proliferation - drug effects Fundamental and applied biological sciences. Psychology HL-60 HL-60 Cells http://www.fao.org/aos/agrovoc#c_1314 http://www.fao.org/aos/agrovoc#c_34335 http://www.fao.org/aos/agrovoc#c_37411 http://www.fao.org/aos/agrovoc#c_4297 http://www.fao.org/aos/agrovoc#c_4314 http://www.fao.org/aos/agrovoc#c_4807 http://www.fao.org/aos/agrovoc#c_7562 Humans LEUCEMIA LEUCEMIE LEUKAEMIA Leukemia - pathology LICHEN LICHENES Lichens - chemistry LIQUENES METABOLITE SECONDAIRE METABOLITOS SECUNDARIOS MICRO-ORGANISME MICROORGANISMOS MICROORGANISMS PROLIFERACION DE TEJIDOS PROLIFERATION DES TISSUS SECONDARY METABOLITES SIMBIONTICO SYMBIONTS SYMBIOTE TISSUE PROLIFERATION triterpene Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology
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Zusammenfassung:	The lichen substance, 16-O-acetyl-leucotylic acid (1), was isolated from an acetone extract of Myelochroa aurulenta and found to exhibit antiproliferative activity against HL-60 human leukemia cells. This is the first report on its anti-leukemia activity (EC 50 =21 μM) which is greater than that of leucotylic acid (2) and the structurally related anti-tumor agent, betulinic acid (4).
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.90419