Elevated 1‐hour post‐load plasma glucose identifies obese youth with abnormal glucose metabolism and an unfavourable inflammatory profile

Summary Context Adults with plasma glucose levels at one hour (1h‐GL) ≥8.6 mmol/L during an oral glucose tolerance test (OGTT) are at increased risk for type 2 diabetes mellitus and present an unfavourable cardiometabolic and inflammatory profile, but relevant data on children are scarce. Objective To investigate if elevated 1h‐GL during OGTT in obese children and adolescents is associated with insulin resistance and specific pro‐inflammatory biomarkers. Research Design and Methods The study group comprised 88 obese children who attended the Outpatient Pediatric Clinic of our Hospital between January and December 2016. Children were divided into two groups according to 1h‐GL during an OGTT: group 1 (n = 57) consisted of those with 1h‐GL