Modeling premature occurrence of acute coronary syndrome with atherogenic and thrombogenic risk factors and gene markers in extended families

Modeling premature occurrence of acute coronary syndrome with atherogenic and thrombogenic risk factors and gene markers in extended families

Background: The interaction between genetic and environmental risk factors in determining premature cardiovascular events has been largely investigated in case–control association studies. By contrast, few family based analyses have been performed so far. Patients/methods: From a series of 2936 subj...

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Veröffentlicht in:Journal of thrombosis and haemostasis 2005-10, Vol.3 (10), p.2238-2244
Hauptverfasser: GRASSI, M., ASSANELLI, D., MOZZINI, C., ALBERTINI, F., SALVADORI, G., ARCHETTI, S., NEGRINI, R., GALEAZZI, G., PEZZINI, A.
Format: Artikel
Sprache:eng
Schlagworte:
Age of Onset
Atherosclerosis - epidemiology
Atherosclerosis - etiology
Atherosclerosis - genetics
families
Family Health
Female
fibrinogen
Fibrinogen - analysis
Genetic Markers
Genotype
homocysteine
Homocysteine - blood
Humans
Male
Markov block‐recursive modeling
Middle Aged
Models, Statistical
Myocardial Infarction - epidemiology
Myocardial Infarction - etiology
Myocardial Infarction - genetics
Pedigree
premature cardiovascular disease
Risk Factors
Thrombosis - epidemiology
Thrombosis - etiology
Thrombosis - genetics
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Zusammenfassung:Background: The interaction between genetic and environmental risk factors in determining premature cardiovascular events has been largely investigated in case–control association studies. By contrast, few family based analyses have been performed so far. Patients/methods: From a series of 2936 subjects aged 45–64, we selected probands who died for a premature (
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/j.1538-7836.2005.01512.x