Expression Analysis of Long Non-Coding RNA HAR1A and HAR1B in HBV-Induced Hepatocullular Carcinoma in Chinese Patients

Expression Analysis of Long Non-Coding RNA HAR1A and HAR1B in HBV-Induced Hepatocullular Carcinoma in Chinese Patients

To determine the clinical relevance of long noncoding RNA (lncRNA) HAR1A and HAR1B expression in hepatocellular carcinoma (HCC). In this study, we enrolled 50 cases of chronic hepatitis B (CHB) without cirrhosis, 50 cases of CHB and liver cirrhosis (LC), and 100 cases of HBV and HCC. The expression...

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Veröffentlicht in:Laboratory medicine 2019-04, Vol.50 (2), p.150-157
Hauptverfasser: Shi, Zhenjing, Luo, Ya, Zhu, Minghui, Zhou, Yu, Zheng, Bingru, Wu, Daoyi, Wang, Shuting, Xie, Xiangbang, Lin, Heping, Yu, Xixiang
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Antisense RNA
Cancer
Carcinoma
Care and treatment
Cohort Studies
Development and progression
Female
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Neoplastic - genetics
Genetic aspects
Genotypes
Health aspects
Hepatitis B
Hepatitis B, Chronic - complications
Hepatitis B, Chronic - epidemiology
Hepatitis B, Chronic - genetics
Hepatitis B, Chronic - metabolism
Hepatocellular carcinoma
Humans
Liver
Liver cancer
Liver cirrhosis
Liver Cirrhosis - complications
Liver Cirrhosis - epidemiology
Liver Cirrhosis - genetics
Liver Cirrhosis - metabolism
Liver Neoplasms - complications
Liver Neoplasms - epidemiology
Liver Neoplasms - genetics
Liver Neoplasms - metabolism
Male
Medical prognosis
Middle Aged
Polymerase chain reaction
Real-Time Polymerase Chain Reaction
RNA
RNA, Untranslated - analysis
RNA, Untranslated - genetics
RNA, Untranslated - metabolism
Transcriptome - genetics
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Zusammenfassung:To determine the clinical relevance of long noncoding RNA (lncRNA) HAR1A and HAR1B expression in hepatocellular carcinoma (HCC). In this study, we enrolled 50 cases of chronic hepatitis B (CHB) without cirrhosis, 50 cases of CHB and liver cirrhosis (LC), and 100 cases of HBV and HCC. The expression profiles of lncRNA HAR1A and HAR1B were analyzed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The expression levels of HAR1A and HAR1B were significantly lower in the HCC group, compared with the CHB and LC groups (P
ISSN:0007-5027
1943-7730
DOI:10.1093/labmed/lmy055