Classification and Personalized Prognosis in Myeloproliferative Neoplasms

Genetic analysis involving 2035 patients with a myeloproliferative disorder identified eight genomic subgroups with distinct clinical phenotypes, risk of leukemic transformation, and event-free survival.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2018-10, Vol.379 (15), p.1416-1430
Hauptverfasser:	Grinfeld, Jacob, Nangalia, Jyoti, Baxter, E. Joanna, Wedge, David C, Angelopoulos, Nicos, Cantrill, Robert, Godfrey, Anna L, Papaemmanuil, Elli, Gundem, Gunes, MacLean, Cathy, Cook, Julia, O’Neil, Laura, O’Meara, Sarah, Teague, Jon W, Butler, Adam P, Massie, Charlie E, Williams, Nicholas, Nice, Francesca L, Andersen, Christen L, Hasselbalch, Hans C, Guglielmelli, Paola, McMullin, Mary F, Vannucchi, Alessandro M, Harrison, Claire N, Gerstung, Moritz, Green, Anthony R, Campbell, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Bayes Theorem Blood cancer Bone marrow Calreticulin - genetics Cancer Cancer therapies Classification Classification schemes Clinical trials Diagnosis Disease Progression Disease-Free Survival DNA, Neoplasm - analysis Exons Genes Genetic transformation Genomes Genomics Humans Janus kinase 2 Janus Kinase 2 - genetics Laboratories Leukemia Medical prognosis Medical research Multivariate Analysis Mutation Myelofibrosis Myeloproliferative Disorders - classification Myeloproliferative Disorders - genetics Patients Phenotype Phenotypes Polycythemia Polycythemia vera Precision Medicine Prognosis Proportional Hazards Models Receptors, Thrombopoietin - genetics Sequence Analysis, DNA Stem cells Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Genetic analysis involving 2035 patients with a myeloproliferative disorder identified eight genomic subgroups with distinct clinical phenotypes, risk of leukemic transformation, and event-free survival.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1716614