Polysaccharide-based film loaded with vitamin C and propolis: A promising device to accelerate diabetic wound healing
[Display omitted] Wound healing can be a painful and time-consuming process in patients with diabetes mellitus. In light of this, the use of wound healing devices could help to accelerate this process. Here, cellulose-based films loaded with vitamin C (VitC) and/or propolis (Prop), two natural compo...
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| Veröffentlicht in: | International journal of pharmaceutics 2018-12, Vol.552 (1-2), p.340-351 |
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| container_title | International journal of pharmaceutics |
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| creator | Voss, Guilherme T. Gularte, Matheus S. Vogt, Ane G. Giongo, Janice L. Vaucher, Rodrigo A. Echenique, Joanna V.Z. Soares, Mauro P. Luchese, Cristiane Wilhelm, Ethel A. Fajardo, André R. |
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Wound healing can be a painful and time-consuming process in patients with diabetes mellitus. In light of this, the use of wound healing devices could help to accelerate this process. Here, cellulose-based films loaded with vitamin C (VitC) and/or propolis (Prop), two natural compounds with attractive properties were engineered. The starting materials and the cellulose-based films were characterized in detail. As assessed, vitamin C can be released from the Cel-PVA/VitC and Cel-PVA/VitC/Prop films in a controlled manner. In vitro antibacterial activity studies showed a reduction of bacteria counts (Escherichia coli and Staphylococcus aureus) after Cel-PVA/VitC, Cel-PVA/Prop, and Cel-PVA/VitC/Prop treatments. Moreover, we examined the antibacterial and wound healing properties of the cellulose-based films in a streptozotocin (STZ)-induced diabetic animal model. Diabetic mice exhibited impaired wound healing while the Cel-PVA/VitC/Prop treatment increased the wound closure. A marked reduction in bacterial counts present in the wound environment of diabetic mice was observed after Cel-PVA/VitC, Cel-PVA/Prop and Cel-PVA/VitC/Prop treatment. Histological analysis demonstrated that the non-treated diabetic mice group did not exhibit adequate wound healing while the treated group with Cel-PVA/VitC and Cel-PVA/VitC/Prop films presented good cicatricial response. Furthermore, these novel eco-friendly films may represent a new therapeutic approach to accelerate diabetic wound healing. |
| doi_str_mv | 10.1016/j.ijpharm.2018.10.009 |
| format | Article |
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Wound healing can be a painful and time-consuming process in patients with diabetes mellitus. In light of this, the use of wound healing devices could help to accelerate this process. Here, cellulose-based films loaded with vitamin C (VitC) and/or propolis (Prop), two natural compounds with attractive properties were engineered. The starting materials and the cellulose-based films were characterized in detail. As assessed, vitamin C can be released from the Cel-PVA/VitC and Cel-PVA/VitC/Prop films in a controlled manner. In vitro antibacterial activity studies showed a reduction of bacteria counts (Escherichia coli and Staphylococcus aureus) after Cel-PVA/VitC, Cel-PVA/Prop, and Cel-PVA/VitC/Prop treatments. Moreover, we examined the antibacterial and wound healing properties of the cellulose-based films in a streptozotocin (STZ)-induced diabetic animal model. Diabetic mice exhibited impaired wound healing while the Cel-PVA/VitC/Prop treatment increased the wound closure. A marked reduction in bacterial counts present in the wound environment of diabetic mice was observed after Cel-PVA/VitC, Cel-PVA/Prop and Cel-PVA/VitC/Prop treatment. Histological analysis demonstrated that the non-treated diabetic mice group did not exhibit adequate wound healing while the treated group with Cel-PVA/VitC and Cel-PVA/VitC/Prop films presented good cicatricial response. Furthermore, these novel eco-friendly films may represent a new therapeutic approach to accelerate diabetic wound healing.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2018.10.009</identifier><identifier>PMID: 30300708</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject><![CDATA[Animals ; Anti-Bacterial Agents - administration & dosage ; Antioxidants - administration & dosage ; Ascorbic Acid - administration & dosage ; Cellulose ; Cellulose - administration & dosage ; Diabetes mellitus ; Diabetes Mellitus, Experimental - drug therapy ; Diabetic wound healing ; Drug Delivery Systems ; Escherichia coli - drug effects ; Escherichia coli - growth & development ; Male ; Mice ; Oryza ; Propolis ; Propolis - administration & dosage ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - growth & development ; Vitamin C ; Wound healing ; Wound Healing - drug effects]]></subject><ispartof>International journal of pharmaceutics, 2018-12, Vol.552 (1-2), p.340-351</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-60f8dca1e27b1c0a69ccda216fbe65eafb2a8a76259d1f6953c7cf1c0386c6203</citedby><cites>FETCH-LOGICAL-c365t-60f8dca1e27b1c0a69ccda216fbe65eafb2a8a76259d1f6953c7cf1c0386c6203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517318307452$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30300708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Voss, Guilherme T.</creatorcontrib><creatorcontrib>Gularte, Matheus S.</creatorcontrib><creatorcontrib>Vogt, Ane G.</creatorcontrib><creatorcontrib>Giongo, Janice L.</creatorcontrib><creatorcontrib>Vaucher, Rodrigo A.</creatorcontrib><creatorcontrib>Echenique, Joanna V.Z.</creatorcontrib><creatorcontrib>Soares, Mauro P.</creatorcontrib><creatorcontrib>Luchese, Cristiane</creatorcontrib><creatorcontrib>Wilhelm, Ethel A.</creatorcontrib><creatorcontrib>Fajardo, André R.</creatorcontrib><title>Polysaccharide-based film loaded with vitamin C and propolis: A promising device to accelerate diabetic wound healing</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>[Display omitted]
Wound healing can be a painful and time-consuming process in patients with diabetes mellitus. In light of this, the use of wound healing devices could help to accelerate this process. Here, cellulose-based films loaded with vitamin C (VitC) and/or propolis (Prop), two natural compounds with attractive properties were engineered. The starting materials and the cellulose-based films were characterized in detail. As assessed, vitamin C can be released from the Cel-PVA/VitC and Cel-PVA/VitC/Prop films in a controlled manner. In vitro antibacterial activity studies showed a reduction of bacteria counts (Escherichia coli and Staphylococcus aureus) after Cel-PVA/VitC, Cel-PVA/Prop, and Cel-PVA/VitC/Prop treatments. Moreover, we examined the antibacterial and wound healing properties of the cellulose-based films in a streptozotocin (STZ)-induced diabetic animal model. Diabetic mice exhibited impaired wound healing while the Cel-PVA/VitC/Prop treatment increased the wound closure. A marked reduction in bacterial counts present in the wound environment of diabetic mice was observed after Cel-PVA/VitC, Cel-PVA/Prop and Cel-PVA/VitC/Prop treatment. Histological analysis demonstrated that the non-treated diabetic mice group did not exhibit adequate wound healing while the treated group with Cel-PVA/VitC and Cel-PVA/VitC/Prop films presented good cicatricial response. Furthermore, these novel eco-friendly films may represent a new therapeutic approach to accelerate diabetic wound healing.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Antioxidants - administration & dosage</subject><subject>Ascorbic Acid - administration & dosage</subject><subject>Cellulose</subject><subject>Cellulose - administration & dosage</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetic wound healing</subject><subject>Drug Delivery Systems</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - growth & development</subject><subject>Male</subject><subject>Mice</subject><subject>Oryza</subject><subject>Propolis</subject><subject>Propolis - administration & dosage</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - growth & development</subject><subject>Vitamin C</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFvEzEQhS0EoqHwE0A-ctkwtlnb4YKqCGilSnCAszVrzxJHu-tg76bqv6-jBK6cPBp9783zY-ytgLUAoT_s13F_2GEe1xKErbs1wOYZWwlrVKM-Gv2crUAZ27TCqCv2qpQ9AGgp1Et2pUABGLArtvxIw2NB76tVDNR0WCjwPg4jHxKGOj_EecePccYxTnzLcQr8kNMhDbF84jeneYwlTr95oGP0xOfEqx0NlHEmHiJ2NEfPH9JSlTvCobKv2Yseh0JvLu81-_X1y8_tbXP__dvd9ua-8Uq3c6Oht8GjIGk64QH1xvuAUui-I90S9p1Ei0bLdhNErzet8sb3lVRWey1BXbP3Z9-a8s9CZXY1a8024ERpKU4KYawE25qKtmfU51RKpt4dchwxPzoB7tS427tL4-7U-GldG6-6d5cTSzdS-Kf6W3EFPp8Bqh89Rsqu-EiTpxAz-dmFFP9z4glNOpaa</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Voss, Guilherme T.</creator><creator>Gularte, Matheus S.</creator><creator>Vogt, Ane G.</creator><creator>Giongo, Janice L.</creator><creator>Vaucher, Rodrigo A.</creator><creator>Echenique, Joanna V.Z.</creator><creator>Soares, Mauro P.</creator><creator>Luchese, Cristiane</creator><creator>Wilhelm, Ethel A.</creator><creator>Fajardo, André R.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20181201</creationdate><title>Polysaccharide-based film loaded with vitamin C and propolis: A promising device to accelerate diabetic wound healing</title><author>Voss, Guilherme T. ; Gularte, Matheus S. ; Vogt, Ane G. ; Giongo, Janice L. ; Vaucher, Rodrigo A. ; Echenique, Joanna V.Z. ; Soares, Mauro P. ; Luchese, Cristiane ; Wilhelm, Ethel A. ; Fajardo, André R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-60f8dca1e27b1c0a69ccda216fbe65eafb2a8a76259d1f6953c7cf1c0386c6203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Antioxidants - administration & dosage</topic><topic>Ascorbic Acid - administration & dosage</topic><topic>Cellulose</topic><topic>Cellulose - administration & dosage</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetic wound healing</topic><topic>Drug Delivery Systems</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - growth & development</topic><topic>Male</topic><topic>Mice</topic><topic>Oryza</topic><topic>Propolis</topic><topic>Propolis - administration & dosage</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Staphylococcus aureus - growth & development</topic><topic>Vitamin C</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Voss, Guilherme T.</creatorcontrib><creatorcontrib>Gularte, Matheus S.</creatorcontrib><creatorcontrib>Vogt, Ane G.</creatorcontrib><creatorcontrib>Giongo, Janice L.</creatorcontrib><creatorcontrib>Vaucher, Rodrigo A.</creatorcontrib><creatorcontrib>Echenique, Joanna V.Z.</creatorcontrib><creatorcontrib>Soares, Mauro P.</creatorcontrib><creatorcontrib>Luchese, Cristiane</creatorcontrib><creatorcontrib>Wilhelm, Ethel A.</creatorcontrib><creatorcontrib>Fajardo, André R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Voss, Guilherme T.</au><au>Gularte, Matheus S.</au><au>Vogt, Ane G.</au><au>Giongo, Janice L.</au><au>Vaucher, Rodrigo A.</au><au>Echenique, Joanna V.Z.</au><au>Soares, Mauro P.</au><au>Luchese, Cristiane</au><au>Wilhelm, Ethel A.</au><au>Fajardo, André R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polysaccharide-based film loaded with vitamin C and propolis: A promising device to accelerate diabetic wound healing</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>552</volume><issue>1-2</issue><spage>340</spage><epage>351</epage><pages>340-351</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>[Display omitted]
Wound healing can be a painful and time-consuming process in patients with diabetes mellitus. In light of this, the use of wound healing devices could help to accelerate this process. Here, cellulose-based films loaded with vitamin C (VitC) and/or propolis (Prop), two natural compounds with attractive properties were engineered. The starting materials and the cellulose-based films were characterized in detail. As assessed, vitamin C can be released from the Cel-PVA/VitC and Cel-PVA/VitC/Prop films in a controlled manner. In vitro antibacterial activity studies showed a reduction of bacteria counts (Escherichia coli and Staphylococcus aureus) after Cel-PVA/VitC, Cel-PVA/Prop, and Cel-PVA/VitC/Prop treatments. Moreover, we examined the antibacterial and wound healing properties of the cellulose-based films in a streptozotocin (STZ)-induced diabetic animal model. Diabetic mice exhibited impaired wound healing while the Cel-PVA/VitC/Prop treatment increased the wound closure. A marked reduction in bacterial counts present in the wound environment of diabetic mice was observed after Cel-PVA/VitC, Cel-PVA/Prop and Cel-PVA/VitC/Prop treatment. Histological analysis demonstrated that the non-treated diabetic mice group did not exhibit adequate wound healing while the treated group with Cel-PVA/VitC and Cel-PVA/VitC/Prop films presented good cicatricial response. Furthermore, these novel eco-friendly films may represent a new therapeutic approach to accelerate diabetic wound healing.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30300708</pmid><doi>10.1016/j.ijpharm.2018.10.009</doi><tpages>12</tpages></addata></record> |
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| subjects | Animals Anti-Bacterial Agents - administration & dosage Antioxidants - administration & dosage Ascorbic Acid - administration & dosage Cellulose Cellulose - administration & dosage Diabetes mellitus Diabetes Mellitus, Experimental - drug therapy Diabetic wound healing Drug Delivery Systems Escherichia coli - drug effects Escherichia coli - growth & development Male Mice Oryza Propolis Propolis - administration & dosage Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Vitamin C Wound healing Wound Healing - drug effects |
| title | Polysaccharide-based film loaded with vitamin C and propolis: A promising device to accelerate diabetic wound healing |
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