Tandem radical cyclization of N-methacryloyl benzamides with CBr4 to construct brominated isoquinolinediones

Tandem radical cyclization of N-methacryloyl benzamides with CBr4 to construct brominated isoquinolinediones

A simple cumene (isopropylbenzene, IPB) promoted auto-oxidation involved tandem radical cyclization of N-methacryloyl benzamides using stable and easy-to-handle CBr4 as the bromine source is described. This strategy provides an efficient and practical approach for the synthesis of bromine containing...

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Veröffentlicht in:Organic & biomolecular chemistry 2018-11, Vol.16 (41), p.7748-7752
Hauptverfasser: Huang, Songhai, Niu, Pengfei, Su, Yingpeng, Hu, Dongcheng, Huo, Congde
Format: Artikel
Sprache:eng
Schlagworte:
Bromination
Bromine
Crystallography
Cumene
Oxidation
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Zusammenfassung:A simple cumene (isopropylbenzene, IPB) promoted auto-oxidation involved tandem radical cyclization of N-methacryloyl benzamides using stable and easy-to-handle CBr4 as the bromine source is described. This strategy provides an efficient and practical approach for the synthesis of bromine containing isoquinolinediones. This method also presents a new way to generate bromine radicals using a mild auto-oxidation pathway.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob01964a