Normal pancreatic volume in adults is influenced by visceral fat, vertebral body width and age
Objectives The aim was to describe the pancreatic volume (PV) in a cohort of subjects with no prior history of pancreatic disease, and to explore the relationship between PV and conventional two-point measurements of the pancreas. Associations between PV, gender, age, abdominal body composition, and...
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| Veröffentlicht in: | Abdominal imaging 2019-03, Vol.44 (3), p.958-966 |
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| description | Objectives
The aim was to describe the pancreatic volume (PV) in a cohort of subjects with no prior history of pancreatic disease, and to explore the relationship between PV and conventional two-point measurements of the pancreas. Associations between PV, gender, age, abdominal body composition, and human height were explored as well.
Methods
CT scans from 204 trauma patients (20–80 years, 100 males) were evaluated. PV was measured with semi-automatic segmentation. Standardized two-point measurements of the pancreas were obtained together with L1 vertebral body size (a proxy for human height) and abdominal body composition. Associations between PV and the other parameters were explored using uni- and multivariate linear regression.
Results
The mean PV was 77.9 ± 21.7(SD) cm
3
with an interindividual variability from 18.8 to 139.8 cm
3
. The transversal diameter of the pancreatic head showed the strongest correlation to PV (
r
= 0.500,
p
|
| doi_str_mv | 10.1007/s00261-018-1793-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2117393618</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2117393618</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-dc8245d2f12f6463bab72960ae3d4d6963d66bb8439371e4cf1e7f02cb1c37713</originalsourceid><addsrcrecordid>eNp1kM1LHTEUxUOxVHn6B3RTAt246NR7k5nMzFLEqiB1U8FVQz7u2JH5eE1mXnn_vRmfVRCEwE24v3NyOIx9RviOAOVJBBAKM8Aqw7KWWfWBHQipVAZQVHsv9_xunx3F-AAAqApEUXxi-xJEXeUSDtjvn2PoTcfXZnCBzNQ6vhm7uSfeDtz4uZsib9MZmm6mwZHndss3bXQUkqox0ze-oTCRXZ529Fv-r_XTH24Gz809HbKPjekiHT3PFbv9cf7r7DK7vrm4Oju9zpwsxZR5V4m88KJB0ahcSWtsKWoFhqTPvaqV9EpZmyLXskTKXYNUNiCcxWRQolyx453vOox_Z4qT7peMXWcGGueoBWKZtAqrhH59gz6McxhSuicKpKhUkSjcUS6MMQZq9Dq0vQlbjaCX_vWuf53610v_enH-8uw82578i-J_2wkQOyCm1XBP4fXr910fAWECjuQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2117032865</pqid></control><display><type>article</type><title>Normal pancreatic volume in adults is influenced by visceral fat, vertebral body width and age</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Kipp, Johannes Peter ; Olesen, Søren Schou ; Mark, Esben Bolvig ; Frederiksen, Lida Changiziyan ; Drewes, Asbjørn Mohr ; Frøkjær, Jens Brøndum</creator><creatorcontrib>Kipp, Johannes Peter ; Olesen, Søren Schou ; Mark, Esben Bolvig ; Frederiksen, Lida Changiziyan ; Drewes, Asbjørn Mohr ; Frøkjær, Jens Brøndum</creatorcontrib><description>Objectives
The aim was to describe the pancreatic volume (PV) in a cohort of subjects with no prior history of pancreatic disease, and to explore the relationship between PV and conventional two-point measurements of the pancreas. Associations between PV, gender, age, abdominal body composition, and human height were explored as well.
Methods
CT scans from 204 trauma patients (20–80 years, 100 males) were evaluated. PV was measured with semi-automatic segmentation. Standardized two-point measurements of the pancreas were obtained together with L1 vertebral body size (a proxy for human height) and abdominal body composition. Associations between PV and the other parameters were explored using uni- and multivariate linear regression.
Results
The mean PV was 77.9 ± 21.7(SD) cm
3
with an interindividual variability from 18.8 to 139.8 cm
3
. The transversal diameter of the pancreatic head showed the strongest correlation to PV (
r
= 0.500,
p
< 0.001). Age, width of the L1 vertebral body, and visceral fat cross-sectional area were all independently associated with PV (all
p
< 0.001), while no independent association was seen for gender (
p
= 0.441).
Conclusions
The pancreatic volume is subject to a large interindividual variability and is associated with age, human height and body composition, while gender had no independent influence on the pancreatic volume. Thus, future studies using PV as an outcome parameter should be evaluated in the context of anthropometric profiles.</description><identifier>ISSN: 2366-004X</identifier><identifier>EISSN: 2366-0058</identifier><identifier>DOI: 10.1007/s00261-018-1793-8</identifier><identifier>PMID: 30298430</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Adults ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Anthropometry ; Body Composition ; Body height ; Body size ; Computed tomography ; Female ; Gastroenterology ; Gender ; Hepatology ; Humans ; Imaging ; Intra-Abdominal Fat - anatomy & histology ; Male ; Males ; Medicine ; Medicine & Public Health ; Middle Aged ; Organ Size ; Pancreas ; Pancreas - anatomy & histology ; Parameters ; Radiology ; Retrospective Studies ; Segmentation ; Sex Factors ; Tomography, X-Ray Computed ; Trauma ; Variability ; Vertebrae ; Young Adult</subject><ispartof>Abdominal imaging, 2019-03, Vol.44 (3), p.958-966</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Abdominal Radiology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-dc8245d2f12f6463bab72960ae3d4d6963d66bb8439371e4cf1e7f02cb1c37713</citedby><cites>FETCH-LOGICAL-c372t-dc8245d2f12f6463bab72960ae3d4d6963d66bb8439371e4cf1e7f02cb1c37713</cites><orcidid>0000-0001-8722-0070</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00261-018-1793-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00261-018-1793-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30298430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kipp, Johannes Peter</creatorcontrib><creatorcontrib>Olesen, Søren Schou</creatorcontrib><creatorcontrib>Mark, Esben Bolvig</creatorcontrib><creatorcontrib>Frederiksen, Lida Changiziyan</creatorcontrib><creatorcontrib>Drewes, Asbjørn Mohr</creatorcontrib><creatorcontrib>Frøkjær, Jens Brøndum</creatorcontrib><title>Normal pancreatic volume in adults is influenced by visceral fat, vertebral body width and age</title><title>Abdominal imaging</title><addtitle>Abdom Radiol</addtitle><addtitle>Abdom Radiol (NY)</addtitle><description>Objectives
The aim was to describe the pancreatic volume (PV) in a cohort of subjects with no prior history of pancreatic disease, and to explore the relationship between PV and conventional two-point measurements of the pancreas. Associations between PV, gender, age, abdominal body composition, and human height were explored as well.
Methods
CT scans from 204 trauma patients (20–80 years, 100 males) were evaluated. PV was measured with semi-automatic segmentation. Standardized two-point measurements of the pancreas were obtained together with L1 vertebral body size (a proxy for human height) and abdominal body composition. Associations between PV and the other parameters were explored using uni- and multivariate linear regression.
Results
The mean PV was 77.9 ± 21.7(SD) cm
3
with an interindividual variability from 18.8 to 139.8 cm
3
. The transversal diameter of the pancreatic head showed the strongest correlation to PV (
r
= 0.500,
p
< 0.001). Age, width of the L1 vertebral body, and visceral fat cross-sectional area were all independently associated with PV (all
p
< 0.001), while no independent association was seen for gender (
p
= 0.441).
Conclusions
The pancreatic volume is subject to a large interindividual variability and is associated with age, human height and body composition, while gender had no independent influence on the pancreatic volume. Thus, future studies using PV as an outcome parameter should be evaluated in the context of anthropometric profiles.</description><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anthropometry</subject><subject>Body Composition</subject><subject>Body height</subject><subject>Body size</subject><subject>Computed tomography</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gender</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Intra-Abdominal Fat - anatomy & histology</subject><subject>Male</subject><subject>Males</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Organ Size</subject><subject>Pancreas</subject><subject>Pancreas - anatomy & histology</subject><subject>Parameters</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Segmentation</subject><subject>Sex Factors</subject><subject>Tomography, X-Ray Computed</subject><subject>Trauma</subject><subject>Variability</subject><subject>Vertebrae</subject><subject>Young Adult</subject><issn>2366-004X</issn><issn>2366-0058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kM1LHTEUxUOxVHn6B3RTAt246NR7k5nMzFLEqiB1U8FVQz7u2JH5eE1mXnn_vRmfVRCEwE24v3NyOIx9RviOAOVJBBAKM8Aqw7KWWfWBHQipVAZQVHsv9_xunx3F-AAAqApEUXxi-xJEXeUSDtjvn2PoTcfXZnCBzNQ6vhm7uSfeDtz4uZsib9MZmm6mwZHndss3bXQUkqox0ze-oTCRXZ529Fv-r_XTH24Gz809HbKPjekiHT3PFbv9cf7r7DK7vrm4Oju9zpwsxZR5V4m88KJB0ahcSWtsKWoFhqTPvaqV9EpZmyLXskTKXYNUNiCcxWRQolyx453vOox_Z4qT7peMXWcGGueoBWKZtAqrhH59gz6McxhSuicKpKhUkSjcUS6MMQZq9Dq0vQlbjaCX_vWuf53610v_enH-8uw82578i-J_2wkQOyCm1XBP4fXr910fAWECjuQ</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Kipp, Johannes Peter</creator><creator>Olesen, Søren Schou</creator><creator>Mark, Esben Bolvig</creator><creator>Frederiksen, Lida Changiziyan</creator><creator>Drewes, Asbjørn Mohr</creator><creator>Frøkjær, Jens Brøndum</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K7-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8722-0070</orcidid></search><sort><creationdate>20190301</creationdate><title>Normal pancreatic volume in adults is influenced by visceral fat, vertebral body width and age</title><author>Kipp, Johannes Peter ; Olesen, Søren Schou ; Mark, Esben Bolvig ; Frederiksen, Lida Changiziyan ; Drewes, Asbjørn Mohr ; Frøkjær, Jens Brøndum</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-dc8245d2f12f6463bab72960ae3d4d6963d66bb8439371e4cf1e7f02cb1c37713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anthropometry</topic><topic>Body Composition</topic><topic>Body height</topic><topic>Body size</topic><topic>Computed tomography</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gender</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Imaging</topic><topic>Intra-Abdominal Fat - anatomy & histology</topic><topic>Male</topic><topic>Males</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Organ Size</topic><topic>Pancreas</topic><topic>Pancreas - anatomy & histology</topic><topic>Parameters</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Segmentation</topic><topic>Sex Factors</topic><topic>Tomography, X-Ray Computed</topic><topic>Trauma</topic><topic>Variability</topic><topic>Vertebrae</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kipp, Johannes Peter</creatorcontrib><creatorcontrib>Olesen, Søren Schou</creatorcontrib><creatorcontrib>Mark, Esben Bolvig</creatorcontrib><creatorcontrib>Frederiksen, Lida Changiziyan</creatorcontrib><creatorcontrib>Drewes, Asbjørn Mohr</creatorcontrib><creatorcontrib>Frøkjær, Jens Brøndum</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Computer Science Collection</collection><collection>Computer Science Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Abdominal imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kipp, Johannes Peter</au><au>Olesen, Søren Schou</au><au>Mark, Esben Bolvig</au><au>Frederiksen, Lida Changiziyan</au><au>Drewes, Asbjørn Mohr</au><au>Frøkjær, Jens Brøndum</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normal pancreatic volume in adults is influenced by visceral fat, vertebral body width and age</atitle><jtitle>Abdominal imaging</jtitle><stitle>Abdom Radiol</stitle><addtitle>Abdom Radiol (NY)</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>44</volume><issue>3</issue><spage>958</spage><epage>966</epage><pages>958-966</pages><issn>2366-004X</issn><eissn>2366-0058</eissn><abstract>Objectives
The aim was to describe the pancreatic volume (PV) in a cohort of subjects with no prior history of pancreatic disease, and to explore the relationship between PV and conventional two-point measurements of the pancreas. Associations between PV, gender, age, abdominal body composition, and human height were explored as well.
Methods
CT scans from 204 trauma patients (20–80 years, 100 males) were evaluated. PV was measured with semi-automatic segmentation. Standardized two-point measurements of the pancreas were obtained together with L1 vertebral body size (a proxy for human height) and abdominal body composition. Associations between PV and the other parameters were explored using uni- and multivariate linear regression.
Results
The mean PV was 77.9 ± 21.7(SD) cm
3
with an interindividual variability from 18.8 to 139.8 cm
3
. The transversal diameter of the pancreatic head showed the strongest correlation to PV (
r
= 0.500,
p
< 0.001). Age, width of the L1 vertebral body, and visceral fat cross-sectional area were all independently associated with PV (all
p
< 0.001), while no independent association was seen for gender (
p
= 0.441).
Conclusions
The pancreatic volume is subject to a large interindividual variability and is associated with age, human height and body composition, while gender had no independent influence on the pancreatic volume. Thus, future studies using PV as an outcome parameter should be evaluated in the context of anthropometric profiles.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30298430</pmid><doi>10.1007/s00261-018-1793-8</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8722-0070</orcidid></addata></record> |
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| subjects | Adult Adults Age Age Factors Aged Aged, 80 and over Anthropometry Body Composition Body height Body size Computed tomography Female Gastroenterology Gender Hepatology Humans Imaging Intra-Abdominal Fat - anatomy & histology Male Males Medicine Medicine & Public Health Middle Aged Organ Size Pancreas Pancreas - anatomy & histology Parameters Radiology Retrospective Studies Segmentation Sex Factors Tomography, X-Ray Computed Trauma Variability Vertebrae Young Adult |
| title | Normal pancreatic volume in adults is influenced by visceral fat, vertebral body width and age |
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