Invited Perspective on “The Molecular Intersection Between Senescence and Major Depression in the Elderly”
Laks offers insight on the article "The Molecular Intersection Between Senescence and Major Depression in the Elderly." The senescence-associated secretory phenotype, together with altered metabolomics, telomere length, and microRNA, provides an elegant model of the enhanced aging process...
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| Veröffentlicht in: | The American journal of geriatric psychiatry 2018-11, Vol.26 (11), p.1106-1107 |
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| container_end_page | 1107 |
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| container_issue | 11 |
| container_start_page | 1106 |
| container_title | The American journal of geriatric psychiatry |
| container_volume | 26 |
| creator | Laks, Jerson |
| description | Laks offers insight on the article "The Molecular Intersection Between Senescence and Major Depression in the Elderly." The senescence-associated secretory phenotype, together with altered metabolomics, telomere length, and microRNA, provides an elegant model of the enhanced aging process in LLD that predisposes and leads to poor outcomes in this population. Dysregulated proteostasis-related pathways are a common link between major depression and Alzheimer disease in persons with comor-bid mild cognitive impairment, strongly suggesting that a common underlying pathophysiologic process contributes to the higher than expected association between these conditions. |
| doi_str_mv | 10.1016/j.jagp.2018.08.007 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1064-7481 |
| ispartof | The American journal of geriatric psychiatry, 2018-11, Vol.26 (11), p.1106-1107 |
| issn | 1064-7481 1545-7214 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2117154834 |
| source | Alma/SFX Local Collection |
| subjects | Aging Genotype & phenotype Mental depression Older people Senescence |
| title | Invited Perspective on “The Molecular Intersection Between Senescence and Major Depression in the Elderly” |
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