Molecular docking, and anti-biofilm activity of gold-complexed sulfonamides on Pseudomonas aeruginosa

The antibacterial activity of sulfadiazine Au-PPh3, sulfadiazine Ph2P-Au-Au-PPh2, sulfamethoxazole Au-PPh3, sulfamethoxazole Ph2P-Au-Au-PPh2, sulfamethoxazole Au-PPh3 were tested against Pseudomonas aeruginosa. The antibacterial activity of sulfonamide was tested against P. aeruginosa through the MIC assay, quantitative analysis of biofilm inhibition and observation of biofilm formation with fluorescence microscopy. Besides, the compounds presented remarkable inhibition of P. aeruginosa biofilm formation. Furthermore, molecular docking was performed to identify the key structural features of these compounds with the binding site of the LasR receptor. •Gold-complexed sulfonamides have antibacterial activity against P. aeruginosa.•Gold-complexed sulfonamides have shown antibiofilm activity.•Sulfonamides reduce the bacteria virulence and spread.•Gold-complexed sulfonamides interacted with LasR active site.