Combined use of biocompatible nanoemulsions and solid microneedles to improve transport of a model NSAID across the skin: In vitro and in vivo studies

This study aimed to investigate the potential of lecithin-based nanoemulsions costabilized by sucrose esters, with and without skin pretreatment with stainless steel microneedles, to improve delivery of aceclofenac, as a model drug, into/across the skin. The characterization revealed favorable dropl...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2018-12, Vol.125, p.110-119
Hauptverfasser:	Ilić, Tanja, Savić, Sanela, Batinić, Bojan, Marković, Bojan, Schmidberger, Markus, Lunter, Dominique, Savić, Miroslav, Savić, Snežana
Format:	Artikel
Sprache:	eng
Schlagworte:	Aceclofenac Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Biological Transport Diclofenac - administration & dosage Diclofenac - analogs & derivatives Diclofenac - pharmacokinetics Differential stripping Drug Delivery Systems Drug Liberation Emulsions In vitro drug release In vitro skin permeation In vivo pharmacokinetics Microinjections Nanoparticles - administration & dosage Needles Rats, Wistar Skin - metabolism Skin Absorption Stainless steel microneedles Sucrose - administration & dosage Sucrose - analogs & derivatives Sucrose - pharmacokinetics Swine
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Beschreibung
Zusammenfassung:	This study aimed to investigate the potential of lecithin-based nanoemulsions costabilized by sucrose esters, with and without skin pretreatment with stainless steel microneedles, to improve delivery of aceclofenac, as a model drug, into/across the skin. The characterization revealed favorable droplet size (about 180 nm), narrow size distribution (
ISSN:	0928-0987 1879-0720
DOI:	10.1016/j.ejps.2018.09.023