Simplified end-to-end continuous manufacturing by feeding API suspensions in twin-screw wet granulation

[Display omitted] This study focussed on investigating the coupling of continuous manufacturing of drug substance and continuous manufacture of drug product. An important step in such an integrated end-to-end continuous manufacturing was envisioned by dosing the API as suspension into a twin-screw w...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2018-12, Vol.133, p.224-231
Hauptverfasser:	Schmidt, Adrian, de Waard, Hans, Moll, Klaus-Peter, Kleinebudde, Peter, Krumme, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Chemistry, Pharmaceutical - methods Compaction Continuous pharmaceutical manufacturing Drug Compounding - methods Excipients - chemistry Formulation Granule and tablet quality Ibuprofen - chemistry Paste Powders - chemistry Suspensions - chemistry Technology, Pharmaceutical - methods Water - chemistry Water content
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