Clinical and biological relevance of genetic alterations in pediatric T‐cell acute lymphoblastic leukemia in Taiwan

Background The leukemogenesis of T‐cell acute lymphoblastic leukemia (T‐ALL) involves multistep processes of genetic alterations. We aimed to determine the genetic alterations including common fusion transcripts, overexpression of T‐cell transcription factor oncogenes, and deletion or mutation of ta...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pediatric blood & cancer 2019-01, Vol.66 (1), p.e27496-n/a
Hauptverfasser:	Yeh, Ting‐Chi, Liang, Der‐Cherng, Liu, Hsi‐Che, Jaing, Tang‐Her, Chen, Shih‐Hsiang, Hou, Jen‐Yin, Yang, Chao‐Ping, Huang, Ying‐Jung, Yao, Hsien‐Wen, Huang, Ting‐Yu, Lin, Tung‐Huei, Shih, Lee‐Yung
Format:	Artikel
Sprache:	eng
Schlagworte:	gene alteration multiplex ligation probe amplification pediatric Taiwan Pediatric Oncology Group T‐cell acute lymphoblastic leukemia
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background The leukemogenesis of T‐cell acute lymphoblastic leukemia (T‐ALL) involves multistep processes of genetic alterations. We aimed to determine the genetic alterations including common fusion transcripts, overexpression of T‐cell transcription factor oncogenes, and deletion or mutation of targeted genes in pediatric T‐ALL in Taiwan as well as their impact on outcomes in those treated with the Taiwan Pediatric Oncology Group‐ALL‐2002 protocol. Procedure Between 1995 and 2015, bone marrow samples obtained from 102 children aged
ISSN:	1545-5009 1545-5017
DOI:	10.1002/pbc.27496