Genome-wide association analysis suggests novel loci for Hashimoto’s thyroiditis

Genome-wide association analysis suggests novel loci for Hashimoto’s thyroiditis

Purpose Hashimoto’s thyroiditis (HT) is the most common form of autoimmune thyroid diseases. Current knowledge of HT genetics is limited, and not a single genome-wide association study (GWAS) focusing exclusively on HT has been performed to date. In order to decipher genetic determinants of HT, we p...

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Veröffentlicht in:Journal of endocrinological investigation 2019-05, Vol.42 (5), p.567-576
Hauptverfasser: Brčić, L., Barić, A., Gračan, S., Brekalo, M., Kaličanin, D., Gunjača, I., Torlak Lovrić, V., Tokić, S., Radman, M., Škrabić, V., Miljković, A., Kolčić, I., Štefanić, M., Glavaš-Obrovac, L., Lessel, D., Polašek, O., Zemunik, T., Barbalić, M., Punda, A., Boraska Perica, V.
Format: Artikel
Sprache:eng
Schlagworte:
Association analysis
Autoimmunity
Endocrinology
Genome-wide association studies
Genomes
Graves' disease
Hypothyroidism
Medicine
Medicine & Public Health
Metabolic Diseases
Original Article
Replication
Thyroid diseases
Thyroid gland
Thyroiditis
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Zusammenfassung:Purpose Hashimoto’s thyroiditis (HT) is the most common form of autoimmune thyroid diseases. Current knowledge of HT genetics is limited, and not a single genome-wide association study (GWAS) focusing exclusively on HT has been performed to date. In order to decipher genetic determinants of HT, we performed the first GWAS followed by replication in a total of 1443 individuals from Croatia. Methods We performed association analysis in a discovery cohort comprising 405 cases and 433 controls. We followed up 13 independent signals ( P  
ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-018-0955-4