Adverse effects of dopamine potentiation by long-term treatment with selegiline

A patient with triosephosphate isomerase (TPI) deficiency exhibited worsening of abnormal involuntary movements of the dystonic type and developed psychiatric symptoms while on selegiline. When selegiline was stopped after 9 years of treatment, abnormal involuntary movements improved to pretreatment...

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Veröffentlicht in:	Movement disorders 2004-01, Vol.19 (1), p.107-109
Hauptverfasser:	Hollán, Susan, Vécsei, László, Magyar, Kálmán
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anemia, Hemolytic, Congenital - enzymology Anemia, Hemolytic, Congenital - genetics Antiparkinson Agents - adverse effects Antiparkinson Agents - therapeutic use Baclofen - adverse effects Baclofen - therapeutic use Basal Ganglia - drug effects Basal Ganglia Diseases - drug therapy Basal Ganglia Diseases - enzymology Basal Ganglia Diseases - genetics Biological and medical sciences Blood Platelets - enzymology Drug Therapy, Combination Dyskinesia, Drug-Induced - diagnosis Dyskinesia, Drug-Induced - etiology Dystonia Musculorum Deformans - drug therapy Dystonia Musculorum Deformans - enzymology Dystonia Musculorum Deformans - genetics Female Genetic Carrier Screening Genotype Glyceraldehyde-3-Phosphate Dehydrogenases - deficiency Glyceraldehyde-3-Phosphate Dehydrogenases - genetics Humans Huntingtin Protein Long-Term Care Male Medical sciences Middle Aged Monoamine Oxidase - blood Monoamine Oxidase - genetics Monoamine Oxidase Inhibitors - adverse effects Monoamine Oxidase Inhibitors - therapeutic use monoamine oxidase-B Nerve Tissue Proteins - genetics Neurologic Examination - drug effects Neurology Neuroprotective Agents - adverse effects Neuroprotective Agents - therapeutic use Nuclear Proteins - genetics Polymerase Chain Reaction Proteins - genetics Psychoses, Substance-Induced - diagnosis Psychoses, Substance-Induced - etiology Reference Values selegiline Selegiline - adverse effects Selegiline - therapeutic use TPI defect Trinucleotide Repeats triosephosphate isomerase
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Zusammenfassung:	A patient with triosephosphate isomerase (TPI) deficiency exhibited worsening of abnormal involuntary movements of the dystonic type and developed psychiatric symptoms while on selegiline. When selegiline was stopped after 9 years of treatment, abnormal involuntary movements improved to pretreatment level and psychiatric behaviour returned to normal. Monoamine oxidase‐B platelet activity was low in this patient. © 2003 Movement Disorder Society
ISSN:	0885-3185 1531-8257
DOI:	10.1002/mds.10641