Investigations on sonofragmentation of hydroxyapatite crystals as a function of strontium incorporation

•Aspect ratio of strontium substituted hydroxyapatite varies with ultrasonication time.•Initial growth of SHA assisted by ultrasonically aided oriented attachment.•Defects form the basis for growth and breakage.•Increase in sonication time leads to fragmentation. Hydroxyapatite (Ca10(PO4)6(OH)2, HA) is chemically similar to the mineral component of bones and hard tissues in mammals. Various cations can substitute calcium in the crystal structure of hydroxyapatite. Among them strontium triggers interest, because strontium incorporated hydroxyapatite increases the number of bone forming sites in addition to having good biocompatibility. In the present investigation strontium substituted hydroxyapatite (SHA) in the compositions range 0, 10, 20, 50 and 100 mol% have been synthesized by precipitation method and subjected to ultrasonic treatment for different time intervals to gain insight on the role of ultrasound in modifying the morphology of SHA. This study reveals that the aspect ratio of SHA varied with the duration of ultrasonication. SHA samples subjected to 5 min ultrasound experienced an increase in aspect ratio. Further increase of ultrasonication time tends to decrease the aspect ratio invariably for all SHA samples indicating particle fragmentation. The extent of sonofragmentation as a function of percentage incorporation of strontium in HA lattice has been studied as a part of the present investigation. This study indicated that strain in the HA lattice has correlation with strontium incorporation, leading to varied extent of sonofragmentation. Also, the investigation suggested that 100% substitution of calcium sites by strontium leads to a relatively lesser strain and hence poor fragmentation. To the best of our knowledge the report on sonofragmentation of HA crystallites as a function of strontium incorporation is first of its kind in the literature.