Electrospun mucosal wound dressings containing styptics for bleeding control

Two major aspects need to be focused to accelerate wound healing of mucosal damages especially in the field of otorhinolaryngology. (i) The problem of application due to the small access during surgery, (ii) the fixation of the wound dressing to reveal a stable healing process. In the present work the high request to a mucosal wound dressing which additionally support hemostasis was addressed. We developed an electrospun fabric made of poly(l-lactide-co-d/l-lactide) (PLA) which can be loaded with the hemostatic agents adrenaline and tranexamic acid to cover mucosal lesions analogues to common skin patches. These loaded electrospun fabrics were demonstrated to be biocompatible, thin and flexible, and thus could be adapted individually to the mucosal defect with respect to localization and size of the lesion. The treatment of mucosal defects with these loaded PLA wound dressings induced a faster and time controlled hemostatic reaction, which significantly improved the healing process. •Novel biocompatible polylactide fleeces could be prepared by electrospinning.•High loading capacities (up to 50% w/w) with haemostatic drugs were achieved.•The materials showed retarded drug release (from hours to days).•Haemostyptic fleeces showed immediate hemostasis during in vivo administration.•The novel fleece degraded in vivo within 4 weeks without inflammatory response.