Islet encapsulation therapy — racing towards the finish line?

Transplanting pancreatic islets in immune-isolating capsules might cure type 1 diabetes mellitus while avoiding the immunosuppression that is normally needed to protect transplanted islets from rejection. A recent study demonstrates that allogeneic islets can survive in capsules with improved biocom...

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Veröffentlicht in:	Nature reviews. Endocrinology 2018-11, Vol.14 (11), p.630-632
Hauptverfasser:	Desai, Tejal A., Tang, Qizhi
Format:	Artikel
Sprache:	eng
Schlagworte:	692/163/2743/137 692/698/1460/1583 692/700/565/545/576 Biocompatibility Bioengineering Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes therapy Endocrinology Experiments Glucagon Glucose Immunology Immunosuppression Immunotherapy Insulin Laboratories Medicine Medicine & Public Health Metabolism News & Views news-and-views Organ transplantation Pancreas transplantation Pancreatic islet transplantation Primates Racing Surgery Type 1 diabetes Universities and colleges
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Beschreibung
Zusammenfassung:	Transplanting pancreatic islets in immune-isolating capsules might cure type 1 diabetes mellitus while avoiding the immunosuppression that is normally needed to protect transplanted islets from rejection. A recent study demonstrates that allogeneic islets can survive in capsules with improved biocompatibility without immunosuppression in non-human primates, bringing us one step closer to applying this therapy in humans.
ISSN:	1759-5029 1759-5037
DOI:	10.1038/s41574-018-0100-7