Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection

Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recogniti...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2018-10, Vol.54 (83), p.11745-11748
Hauptverfasser:	Nishihara, Tatsuya, Kuno, Satoshi, Nonaka, Hiroshi, Tabata, Sho, Saito, Natsumi, Fukuda, Shinji, Tomita, Masaru, Sando, Shinsuke, Soga, Tomoyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - analogs & derivatives Acetaminophen - metabolism Animals Antigens, Neoplasm - analysis Antigens, Neoplasm - metabolism beta-Galactosidase - metabolism Biomarkers Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Cell Line, Tumor Galactosidase Humans Mice Neoplasms - diagnosis Neoplasms - metabolism Staining and Labeling - methods Tumors
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Beschreibung
Zusammenfassung:	Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c8cc06068a