Editorial commentary: Epithelial-to-Mesenchymal transition and G protein-coupled receptors: A novel possibility for cardiac regeneration?

Various metabolic disorders like obesity, diabetes and high blood pressure sequentially cause numerous CVDs like hypertension, cardiomyopathies, cardiac arrest, cardiac valve calcification and arrhythmias among others [1]. In a different study, selective serotonin reuptake inhibitor (SSRI) Fluoxetine lead to dilated cardiomyopathy in rodents and cardiac malfunctions in humans, putting question mark over prenatal SSRI treatment [17]. [...]this review emphasizes the very central mechanism of embryonic and disease growth modulation through GPCRs, which can have tremendous clinical potential in cardiovascular disease managements.