Changes in CREB (SER133) Content and DNA-Binding Activity of Transcriptional Factors in Rat Brain Cells against the Background of Ladasten Exposure

We studied the effects of single administration of ladasten (50 mg/kg) on the level of transcriptional factor CREB (cyclic AMP response binding element protein) phosphorylated by Ser133 in rat striatum, hypothalamus, and hippocampus. Transcriptional factors with affected DNA-binding activity were id...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2009-05, Vol.147 (5), p.599-602
Hauptverfasser:	Salimgareeva, M. Kh, Vakhitova, Yu. V, Yamidanov, R. S, Sadovnikov, S. V, Seredenin, S. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - toxicity Animals Biomedical and Life Sciences Biomedicine Brain - drug effects Brain - metabolism Cell Biology Cyclic AMP Response Element-Binding Protein - metabolism DNA - metabolism hippocampus Hippocampus - drug effects Hippocampus - metabolism hypothalamus Hypothalamus - drug effects Hypothalamus - metabolism Internal Medicine Laboratory Medicine ladasten Male Pathology Pharmacology and Toxicology Protein Binding - drug effects Rats striatum transcription factors
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Zusammenfassung:	We studied the effects of single administration of ladasten (50 mg/kg) on the level of transcriptional factor CREB (cyclic AMP response binding element protein) phosphorylated by Ser133 in rat striatum, hypothalamus, and hippocampus. Transcriptional factors with affected DNA-binding activity were identified in brain cells.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-009-0573-4