Isolation, structure elucidation and biological activities of trichofumins A, B, C and D, new 11 and 13mer peptaibols from Trichoderma sp. HKI 0276

Trichofumins A–D were isolated from cultures of Trichoderma sp. HKI 0276 as new 11 and 13mer peptaibols. Similar to 15mer peptaibols they promote morphogenesis of the fungus Phoma destructiva and cause hypothermia in mice as a characteristic of neuroleptic activity. Membrane measurements using a syn...

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Veröffentlicht in:	Journal of peptide science 2003-11, Vol.9 (11-12), p.810-816
Hauptverfasser:	Berg, Albrecht, Grigoriev, Pavel A., Degenkolb, Thomas, Neuhof, Torsten, Härtl, Albert, Schlegel, Brigitte, Gräfe, Udo
Format:	Artikel
Sprache:	eng
Schlagworte:	11 and 13mer peptaibols effects on fungal morphogenesis membrane activity Phoma pigment formation structure elucidation Trichoderma trichofumins
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Zusammenfassung:	Trichofumins A–D were isolated from cultures of Trichoderma sp. HKI 0276 as new 11 and 13mer peptaibols. Similar to 15mer peptaibols they promote morphogenesis of the fungus Phoma destructiva and cause hypothermia in mice as a characteristic of neuroleptic activity. Membrane measurements using a synthetic BLM model showed that A, B, C and D increased membrane permeability for cations in a similar manner as was shown for larger peptaibols but with comparably lower efficiency. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.
ISSN:	1075-2617 1099-1387
DOI:	10.1002/psc.498