Temperature-dependent Regulation of Antisense Activity Using a DNA/poly(N-isopropylacrylamide) Conjugate

Temperature-dependent Regulation of Antisense Activity Using a DNA/poly(N-isopropylacrylamide) Conjugate

We prepared a novel antisense reagent comprising of oligodeoxynucleotides (ODNs) and a thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm). The conjugate demonstrated stimuli-responsive regulation of gene expression via conformational change of the polymer chain.

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Veröffentlicht in:Chemistry letters 2003-11, Vol.32 (11), p.986-987
Hauptverfasser: Murata, Masaharu, Kaku, Wataru, Anada, Takahisa, Sato, Yoshikuni, Maeda, Mizuo, Katayama, Yoshiki
Format: Artikel
Sprache:eng
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Zusammenfassung:We prepared a novel antisense reagent comprising of oligodeoxynucleotides (ODNs) and a thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm). The conjugate demonstrated stimuli-responsive regulation of gene expression via conformational change of the polymer chain.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2003.986