Parathyroid changes after high dose radioactive iodine in patients with thyroid cancer

Objective The study aimed to investigate the effect of high dose radioactive iodine (RAI) on parathyroid function in patients with differentiated thyroid cancer. Methods Nineteen patients (8 men/11 women, age 46.5 ± 13.2 years) undergoing RAI for thyroid remnant ablation were enrolled in the study....

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Veröffentlicht in:	Annals of nuclear medicine 2009-07, Vol.23 (5), p.437-441
Hauptverfasser:	Guven, Aytekin, Salman, Serpil, Boztepe, Harika, Yarman, Sema, Tanakol, Refik, Azizlerli, Halil, Alagol, Faruk
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - blood Female Humans Imaging Iodine Radioisotopes - administration & dosage Iodine Radioisotopes - adverse effects Iodine Radioisotopes - therapeutic use Male Medicine Medicine & Public Health Middle Aged Nuclear Medicine Original Article Parathyroid Glands - metabolism Parathyroid Glands - physiopathology Parathyroid Glands - radiation effects Parathyroid Hormone - blood Radiation Dosage Radiology Radiotherapy - adverse effects Radiotherapy Dosage Thyroid Neoplasms - blood Thyroid Neoplasms - radiotherapy Time Factors
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Zusammenfassung:	Objective The study aimed to investigate the effect of high dose radioactive iodine (RAI) on parathyroid function in patients with differentiated thyroid cancer. Methods Nineteen patients (8 men/11 women, age 46.5 ± 13.2 years) undergoing RAI for thyroid remnant ablation were enrolled in the study. The biochemical parameters related to parathyroid function [serum calcium (Ca), phosphate (P), creatinine (Cr), alkaline phosphatase (ALP), intact parathyroid hormone (iPTH), urinary Ca, cAMP concentrations and the maximum tubular capacity for phosphate per unit volume of glomerular filtrate (TmP/GFR)] were evaluated at baseline and at the 1st, 3rd, 6th and 12th months of RAI administration. SPSS 15.0 was used for statistical analysis. Results For all patients, thyroid-stimulating hormone levels were >30 U/ml at baseline and
ISSN:	0914-7187 1864-6433
DOI:	10.1007/s12149-009-0270-4