Microenvironmental cues in cancer stemness

Intra-tumour heterogeneity manifests both at the level of mutational burden, and at a functional level within genetically homogenous populations. A new modelling approach suggests stemness within colorectal tumours is defined by microenvironmental cues secreted from cancer-associated fibroblasts rat...

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Veröffentlicht in:	Nature cell biology 2018-10, Vol.20 (10), p.1102-1104
Hauptverfasser:	Flanagan, D. J., Hodder, M. C., Sansom, O. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67 631/67/1504/1885 631/67/327 631/67/71 Biomedical and Life Sciences Cancer Cancer cells Cancer Research Cell Biology Colonic Neoplasms Colorectal cancer Cues Developmental Biology Displays (Marketing) Fibroblasts Gene mutation Heterogeneity Humans Life Sciences Neoplastic Stem Cells News & Views news-and-views Population genetics Stem Cells Tumor Microenvironment Tumors Universities and colleges
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Beschreibung
Zusammenfassung:	Intra-tumour heterogeneity manifests both at the level of mutational burden, and at a functional level within genetically homogenous populations. A new modelling approach suggests stemness within colorectal tumours is defined by microenvironmental cues secreted from cancer-associated fibroblasts rather than cell-intrinsic properties.
ISSN:	1465-7392 1476-4679
DOI:	10.1038/s41556-018-0210-4