Optimal surgical margin for infiltrative soft tissue sarcomas: Assessing the efficacy of excising beyond the infiltration

Background Tumor infiltration in soft tissue sarcoma (STS) is known to correlate with an inadequate surgical margin and poor local control. This study aims to determine whether the radiological infiltration (R‐inf) in STS cor relates with histological infiltration (H‐inf) and to devise methods to determine a resection margin for infiltrative STS. Methods We reviewed the medical records of 145 patients with high‐grade STS. We measured the R‐inf on short‐T1 inversion recovery or gadolinium‐enhanced fat‐suppressed (GdFS) magnetic resonance imaging. In addition, we assessed H‐inf as the infiltrative growth of atypical tumor cells. The local control rate (LCR) was assessed using the Kaplan‐Meier method. Results A statistically significant positive correlation was found between H‐inf and R‐inf (P