CHANGES IN CEREBROSPINAL FLUID CONCENTRATION OF OXIDATIVE STRESS MARKERS DURING CHEMOTHERAPY OF ACUTE LYMPHOBLASTIC LEUKAEMIA IN CHILDREN

In this study we advised question whether cerebrospinal fluid oxidative stress markers are associated with neurotoxicity of chemotherapy of acute lymphoblastic leukaemia (ALL). Examination of 38 ALL patients revealed a statistically significant increase in 8-isoprostane and decrease in total antioxidative capacity during the treatment Dynamic analysis revealed a statistically significant increase in isoprostane starting on the 59 super(th) day of the treatment when the levels were highest and remained raised during all the treatment course. The mean 8-isoprostane level at the diagnosis was 9.05 plus or minus 5.12 pg/ml, and no correlation with initial leukocytosis, organomegaly and lactate dehydrogenase level was noted. Dynamic data analysis revealed a statistically significant increase in 8-isoprostane on the 59 super(th) day of the treatment (24.85 plus or minus 26.28) and at four points during consolidation phase (17.28 plus or minus 8.09; 22.72 plus or minus 21.79; 24.92 plus or minus 22.74; 32.32 plus or minus 26.85) as compared to its level at the diagnosis (P