Food protein–induced enterocolitis syndrome: Increased prevalence of this great unknown—results of the PREVALE study

[...]the cumulative incidence of FPIES was (1) 0.35% for cow's milk protein, (2) 0.26% for fish, and (3) 0.09% for egg yolk. First and second doses were separated by 45 minutes and second and third doses by 2 hours. Case Sex Age of onset (mo) Trigger food Diagnostic criteria for patients presenting with possible FPIES Diagnostic criteria for the interpretation of OFCs in patients with a history of possible or confirmed FPIES Age of OFC (mo) Treatment Recovery Case 1 Male 4 Cow's milk (infant formula) With lower doses of cow's milk, intermittent vomiting with failure to thrive (chronic FPIES) Vomiting in the 1-4-h period after ingestion of the cow's milk protein without allergic skin or respiratory symptoms Extreme lethargy and marked pallor with the reaction 13 No No Case 2 Male 4 Cow's milk (infant formula) Vomiting in the 1-4-h period after ingestion of the cow's milk protein without allergic skin or respiratory symptoms More episodes of repetitive vomiting after eating the same suspect food Vomiting in the 1-4-h period after ingestion of the cow's milk protein without allergic skin or respiratory symptoms Extreme lethargy and marked pallor with the reaction Diarrhea 5-10 h after food ingestion 4 Intravenous fluid support Ondansetron No Case 3 Female 4 Cow's milk (infant formula) Vomiting in the 1-4-h period after ingestion of the cow's milk protein without allergic skin or respiratory symptoms More episodes of repetitive vomiting after eating the same suspect food Extreme lethargy and marked pallor with the reaction Need for emergency department visit with any suspected reaction OFC was not conducted because of repeated reactions to cow's milk protein. Patient meets diagnostic criteria for acute FPIES — — No Case 6 Male 13 Fish Vomiting in the 1-4-h period after ingestion of hake without allergic skin or respiratory symptoms One more episode of repetitive vomiting after eating the same suspect food Need for emergency department visit with the reaction Vomiting in the 1-4-h period after ingestion of the cow's milk protein without allergic skin or respiratory symptoms Extreme lethargy and marked pallor with the reaction 23 Intravenous fluid support Ondansetron No Case 7 Female 15 Fish Vomiting in the 1-4-hour period after ingestion of hake without allergic skin or respiratory symptoms One more episode of repetitive vomiting after eating the same suspect food Vomiting in the 1-4-h period after ingestion of the cow's milk protein without allergic skin or re