Design, synthesis, in vitro, in vivo and in silico pharmacological characterization of antidiabetic N-Boc-l-tyrosine-based compounds

[Display omitted] •Five N-Boc-l-tyrosine derivatives were designed as antidiabetic compounds.•Compounds 1 and 3 showed polypharmacological activities in the in vitro assays.•Both compounds were orally actives in the in vivo diabetes mellitus mice model.•1 and 3 could be considered as promising multi...

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Veröffentlicht in:Biomedicine & pharmacotherapy 2018-12, Vol.108, p.670-678
Hauptverfasser: Herrera-Rueda, Miguel Ángel, Tlahuext, Hugo, Paoli, Paolo, Giacoman-Martínez, Abraham, Almanza-Pérez, Julio César, Pérez-Sánchez, Horacio, Gutiérrez-Hernández, Abraham, Chávez-Silva, Fabiola, Dominguez-Mendoza, Elix Alberto, Estrada-Soto, Samuel, Navarrete-Vazquez, Gabriel
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Sprache:eng
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