Design, synthesis, in vitro, in vivo and in silico pharmacological characterization of antidiabetic N-Boc-l-tyrosine-based compounds
[Display omitted] •Five N-Boc-l-tyrosine derivatives were designed as antidiabetic compounds.•Compounds 1 and 3 showed polypharmacological activities in the in vitro assays.•Both compounds were orally actives in the in vivo diabetes mellitus mice model.•1 and 3 could be considered as promising multi...
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Veröffentlicht in: | Biomedicine & pharmacotherapy 2018-12, Vol.108, p.670-678 |
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Hauptverfasser: | , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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