Site-Selective Ni-Catalyzed Reductive Coupling of α‑Haloboranes with Unactivated Olefins

Site-Selective Ni-Catalyzed Reductive Coupling of α‑Haloboranes with Unactivated Olefins

A mild, chemo- and site-selective catalytic protocol that allows for incorporating an alkylboron fragment into unactivated olefins is described. The use of internal olefins enables C–C bond-formation at remote sp 3 C–H sites, constituting a complementary and conceptually different approach to existi...

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Veröffentlicht in:Journal of the American Chemical Society 2018-10, Vol.140 (40), p.12765-12769
Hauptverfasser: Sun, Shang-Zheng, Börjesson, Marino, Martin-Montero, Raul, Martin, Ruben
Format: Artikel
Sprache:eng
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Zusammenfassung:A mild, chemo- and site-selective catalytic protocol that allows for incorporating an alkylboron fragment into unactivated olefins is described. The use of internal olefins enables C–C bond-formation at remote sp 3 C–H sites, constituting a complementary and conceptually different approach to existing borylation techniques that are currently available at sp 3 centers.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.8b09425