Disease-free Survival and Local Recurrence After Laparoscopic-assisted Resection or Open Resection for Rectal Cancer: The Australasian Laparoscopic Cancer of the Rectum Randomized Clinical Trial

OBJECTIVE:The aim of the study was to determine the efficacy of laparoscopic rectal resection (Lap) versus open laparotomy and rectal resection (Open) for rectal cancer on locoregional recurrence (LRR) and disease-free survival (DFS) at 2 years. SUMMARY BACKGROUND DATA:Although a Lap approach to col...

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Veröffentlicht in:	Annals of surgery 2019-04, Vol.269 (4), p.596-602
Hauptverfasser:	Stevenson, Andrew R. L., Solomon, Michael J., Brown, Christopher S. B., Lumley, John W., Hewett, Peter, Clouston, Andrew D., Gebski, Val J., Wilson, Kate, Hague, Wendy, Simes, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - epidemiology Adenocarcinoma - surgery Aged Digestive System Surgical Procedures - methods Disease-Free Survival Female Humans Laparoscopy Laparotomy - methods Male Middle Aged Neoplasm Recurrence, Local - epidemiology Rectal Neoplasms - epidemiology Rectal Neoplasms - surgery
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Zusammenfassung:	OBJECTIVE:The aim of the study was to determine the efficacy of laparoscopic rectal resection (Lap) versus open laparotomy and rectal resection (Open) for rectal cancer on locoregional recurrence (LRR) and disease-free survival (DFS) at 2 years. SUMMARY BACKGROUND DATA:Although a Lap approach to colon cancer surgery may offer similar oncological outcomes to Open with potentially less morbidity, this remains to be clearly established for the treatment of rectal cancer. METHODS:A randomized, multicenter noninferiority phase 3 trial of 475 patients with T1 to T3 rectal adenocarcinoma
ISSN:	0003-4932 1528-1140
DOI:	10.1097/SLA.0000000000003021