PI 3-Kinase Signaling: AKTing up inside the Cell

PI 3-Kinase Signaling: AKTing up inside the Cell

In this issue of Molecular Cell, Liu et al. (2018) show that PI34P2 and PIP3, the lipid products of class I phosphoinositide 3-kinase (PI3K), display distinct spatiotemporal kinetics in cells that result in differential activation of the effectors AKT1, AKT2, and AKT3. In this issue of Molecular Cel...

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Veröffentlicht in:Molecular cell 2018-09, Vol.71 (6), p.875-876
Hauptverfasser: Toker, Alex, Dibble, Christian C.
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Sprache:eng
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Phosphatidylinositol 3-Kinase
Phosphatidylinositol 3-Kinases
Phosphatidylinositols
Protein Isoforms
Proto-Oncogene Proteins c-akt
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description In this issue of Molecular Cell, Liu et al. (2018) show that PI34P2 and PIP3, the lipid products of class I phosphoinositide 3-kinase (PI3K), display distinct spatiotemporal kinetics in cells that result in differential activation of the effectors AKT1, AKT2, and AKT3. In this issue of Molecular Cell, Liu et al. (2018) show that PI34P2 and PIP3, the lipid products of class I phosphoinositide 3-kinase (PI3K), display distinct spatiotemporal kinetics in cells that result in differential activation of the effectors AKT1, AKT2, and AKT3.
doi_str_mv 10.1016/j.molcel.2018.09.006
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subjects Phosphatidylinositol 3-Kinase
Phosphatidylinositol 3-Kinases
Phosphatidylinositols
Protein Isoforms
Proto-Oncogene Proteins c-akt
title PI 3-Kinase Signaling: AKTing up inside the Cell
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