PI 3-Kinase Signaling: AKTing up inside the Cell

In this issue of Molecular Cell, Liu et al. (2018) show that PI34P2 and PIP3, the lipid products of class I phosphoinositide 3-kinase (PI3K), display distinct spatiotemporal kinetics in cells that result in differential activation of the effectors AKT1, AKT2, and AKT3. In this issue of Molecular Cel...

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Veröffentlicht in:	Molecular cell 2018-09, Vol.71 (6), p.875-876
Hauptverfasser:	Toker, Alex, Dibble, Christian C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Phosphatidylinositol 3-Kinase Phosphatidylinositol 3-Kinases Phosphatidylinositols Protein Isoforms Proto-Oncogene Proteins c-akt
Online-Zugang:	Volltext
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Zusammenfassung:	In this issue of Molecular Cell, Liu et al. (2018) show that PI34P2 and PIP3, the lipid products of class I phosphoinositide 3-kinase (PI3K), display distinct spatiotemporal kinetics in cells that result in differential activation of the effectors AKT1, AKT2, and AKT3. In this issue of Molecular Cell, Liu et al. (2018) show that PI34P2 and PIP3, the lipid products of class I phosphoinositide 3-kinase (PI3K), display distinct spatiotemporal kinetics in cells that result in differential activation of the effectors AKT1, AKT2, and AKT3.
ISSN:	1097-2765 1097-4164
DOI:	10.1016/j.molcel.2018.09.006