Discrete Delta Estimation of the Variance of the Logistic Scores Estimator of ED50

A discrete delta method is applied to estimation of the standard error of the logistic scores estimator of ED50 in quantal bioassay. Results of a simulation study suggest that the standard error estimator is useful for assessing the precision of the ED50 estimate and for interval estimation of ED50.

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Bibliographische Detailangaben
Veröffentlicht in:	Biometrical journal 1999-03, Vol.41 (1), p.45-51
Hauptverfasser:	Cobb, E. Benton, Church, J.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Applications Bioassay Discrete delta method ED50 Exact sciences and technology Linear inference, regression Logistic scores Mathematics Medical sciences Probability and statistics Sciences and techniques of general use Standard error estimator Statistics
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Beschreibung
Zusammenfassung:	A discrete delta method is applied to estimation of the standard error of the logistic scores estimator of ED50 in quantal bioassay. Results of a simulation study suggest that the standard error estimator is useful for assessing the precision of the ED50 estimate and for interval estimation of ED50.
ISSN:	0323-3847 1521-4036
DOI:	10.1002/(SICI)1521-4036(199903)41:1<45::AID-BIMJ45>3.0.CO;2-6