Human Metabolism of Arsenobetaine Ingested with Fish

1 Six volunteers ingested 74As-labelled arsenobetaine with a fish meal. The retention and distribution of the tracer were studied by body radioactivity measurements. 2 The tracer became rapidly dispersed in soft tissues, with no major concentration in any localized organ or region. 3 In all subjects < 1% of the ingested activity remained in the body after 24 days. 4 Any losses from the skin were minor in relation to those by other routes of excretion.