Effect of p-aminopropiophenone (PAPP), a cyanide antidote, on cyanide given by intravenous infusion

1 Beagle bitches were infused with potassium cyanide solution after protection with p-aminopropiophenone (PAPP). 2 Methaemoglobin levels fell very rapidly after the start of the infusion. 3 Whole blood and plasma cyanide estimations revealed that most of the cyanide was sequestered inside the red ce...

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Veröffentlicht in:	Human & experimental toxicology 1987-03, Vol.6 (2), p.133-137
Hauptverfasser:	Bright, J.E., Marrs, T.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Cyanides - antagonists & inhibitors Cyanides - blood Dogs Female Medical sciences Metals and various inorganic compounds Methemoglobin - metabolism Potassium Cyanide - antagonists & inhibitors Propiophenones - pharmacology Toxicology
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Beschreibung
Zusammenfassung:	1 Beagle bitches were infused with potassium cyanide solution after protection with p-aminopropiophenone (PAPP). 2 Methaemoglobin levels fell very rapidly after the start of the infusion. 3 Whole blood and plasma cyanide estimations revealed that most of the cyanide was sequestered inside the red cells. 4 Animals survived a supralethal dose of cyanide when protected with PAPP.
ISSN:	0144-5952 0960-3271
DOI:	10.1177/096032718700600205