Prognostic Value of Early Evaluation of Left Ventricular Dyssynchrony After Myocardial Infarction

Purpose Dispersion in the contraction of the normally coordinate ventricular system, referred to as left ventricular (LV) dyssynchrony, is constantly observed at different grades of severity after myocardial infarction (MI). We aimed to investigate the prognostic value of early dyssynchrony in adverse cardiac events after MI in a rat model using the quantified gated single photon emission tomography (SPECT; QGS) software. Procedures After thoracotomy, the left coronary arteries of 16 rats were occluded and reperfused. SPECT was performed with [ 99m Tc]methoxyisobutylisonitrile 3 days, 1 week, 2 weeks, 4 weeks, and 8 weeks after MI. The phase analysis parameters including mean phase standard deviation (PSD), bandwidth (BW), entropy, and LV function were analyzed by the QGS software. A receiver operating characteristic curve was used to explore the predictors for cardiac death and severe cardiac failure (ejection fraction [EF]