Glycolysis Inhibitors Monoiodoacetate and 2-Deoxyglucose as Antitumor Agents: Experimental Study on Lewis Lung Carcinoma Model
Antitumor effects of glycolysis inhibitors monoiodoacetate and 2-deoxyglucose were studied on Lewis lung carcinoma model. Monoiodoacetate exhibited antitumor and antimetastatic activities, being not inferior of methotrexate (reference drug); however, the preparation also demonstrated high systemic t...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2018-09, Vol.165 (5), p.695-697 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Korshunov, D. A. Klimov, I. A. Ivanov, V. V. Kondakova, I. V. |
| description | Antitumor effects of glycolysis inhibitors monoiodoacetate and 2-deoxyglucose were studied on Lewis lung carcinoma model. Monoiodoacetate exhibited antitumor and antimetastatic activities, being not inferior of methotrexate (reference drug); however, the preparation also demonstrated high systemic toxicity. 2-Deoxyglucose exhibited only antitumor effect, while its antimetastatic activity did not differ from the result in the group without treatment. |
| doi_str_mv | 10.1007/s10517-018-4244-1 |
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Monoiodoacetate exhibited antitumor and antimetastatic activities, being not inferior of methotrexate (reference drug); however, the preparation also demonstrated high systemic toxicity. 2-Deoxyglucose exhibited only antitumor effect, while its antimetastatic activity did not differ from the result in the group without treatment.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-018-4244-1</identifier><identifier>PMID: 30225703</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Antitumor activity ; Antitumor agents ; Biomedical and Life Sciences ; Biomedicine ; Carcinoma ; Carcinoma, Lewis Lung - drug therapy ; Carcinoma, Lewis Lung - metabolism ; Carcinoma, Lewis Lung - pathology ; Cell Biology ; Deoxyglucose ; Deoxyglucose - pharmacology ; Glucose metabolism ; Glycolysis ; Glycolysis - drug effects ; Internal Medicine ; Iodoacetic Acid - pharmacology ; Laboratory Medicine ; Lung cancer ; Lung carcinoma ; Lung Neoplasms - drug therapy ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Lymphatic Metastasis - prevention & control ; Male ; Methotrexate ; Methotrexate - pharmacology ; Mice ; Mice, Inbred C57BL ; Pathology ; Toxicity ; Treatment Outcome ; Tumor Burden - drug effects</subject><ispartof>Bulletin of experimental biology and medicine, 2018-09, Vol.165 (5), p.695-697</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, (2018). 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A.</creatorcontrib><creatorcontrib>Ivanov, V. V.</creatorcontrib><creatorcontrib>Kondakova, I. V.</creatorcontrib><title>Glycolysis Inhibitors Monoiodoacetate and 2-Deoxyglucose as Antitumor Agents: Experimental Study on Lewis Lung Carcinoma Model</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Antitumor effects of glycolysis inhibitors monoiodoacetate and 2-deoxyglucose were studied on Lewis lung carcinoma model. Monoiodoacetate exhibited antitumor and antimetastatic activities, being not inferior of methotrexate (reference drug); however, the preparation also demonstrated high systemic toxicity. 2-Deoxyglucose exhibited only antitumor effect, while its antimetastatic activity did not differ from the result in the group without treatment.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antitumor activity</subject><subject>Antitumor agents</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Carcinoma</subject><subject>Carcinoma, Lewis Lung - drug therapy</subject><subject>Carcinoma, Lewis Lung - metabolism</subject><subject>Carcinoma, Lewis Lung - pathology</subject><subject>Cell Biology</subject><subject>Deoxyglucose</subject><subject>Deoxyglucose - pharmacology</subject><subject>Glucose metabolism</subject><subject>Glycolysis</subject><subject>Glycolysis - drug effects</subject><subject>Internal Medicine</subject><subject>Iodoacetic Acid - pharmacology</subject><subject>Laboratory Medicine</subject><subject>Lung cancer</subject><subject>Lung carcinoma</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Lymphatic Metastasis - prevention & control</subject><subject>Male</subject><subject>Methotrexate</subject><subject>Methotrexate - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Pathology</subject><subject>Toxicity</subject><subject>Treatment Outcome</subject><subject>Tumor Burden - drug effects</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1ksFvFCEUxidGY9fqH-DFkJiYXqYCw-ww3jZrrU3WeFDPhIE3szQMrMDEzsW_vUy2ams0HMh7_L4PHvmK4iXB5wTj5m0kuCZNiQkvGWWsJI-KFambquSUksfFCmeoZJzzk-JZjNdLidfkaXFSYUrrBler4uelnZW3czQRXbm96UzyIaJP3nnjtZcKkkyApNOIlu_B38yDnZSPuRXRxiWTptEHtBnApfgOXdwcIJgxF9KiL2nSM_IO7eBHtt9NbkBbGZRxfpT5Cg32efGklzbCi7v9tPj24eLr9mO5-3x5td3sSsUanPIMStJaKs37NWYN7aFjqoFaadxU7ZpWRLcU95xoWXe6hVZ2as2BN4QRplpdnRZnR99D8N8niEmMJiqwVjrwUxSU4LainNdtRl__hV77Kbj8uoXimPKW3aMGaUEY1_sUpFpMxaauG16teYUzdf4PKi8No1HeQW9y_4HgzT3BHqRN--jtlIx38SFIjqAKPsYAvTjkf5dhFgSLJRziGA6RwyGWcAiSNa_uJpu6EfRvxa80ZIAegZiP3ADhz-j_d70F1TXDCw</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Korshunov, D. 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Monoiodoacetate exhibited antitumor and antimetastatic activities, being not inferior of methotrexate (reference drug); however, the preparation also demonstrated high systemic toxicity. 2-Deoxyglucose exhibited only antitumor effect, while its antimetastatic activity did not differ from the result in the group without treatment.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30225703</pmid><doi>10.1007/s10517-018-4244-1</doi><tpages>3</tpages></addata></record> |
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| subjects | Animals Antineoplastic Agents - pharmacology Antitumor activity Antitumor agents Biomedical and Life Sciences Biomedicine Carcinoma Carcinoma, Lewis Lung - drug therapy Carcinoma, Lewis Lung - metabolism Carcinoma, Lewis Lung - pathology Cell Biology Deoxyglucose Deoxyglucose - pharmacology Glucose metabolism Glycolysis Glycolysis - drug effects Internal Medicine Iodoacetic Acid - pharmacology Laboratory Medicine Lung cancer Lung carcinoma Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Lymphatic Metastasis - prevention & control Male Methotrexate Methotrexate - pharmacology Mice Mice, Inbred C57BL Pathology Toxicity Treatment Outcome Tumor Burden - drug effects |
| title | Glycolysis Inhibitors Monoiodoacetate and 2-Deoxyglucose as Antitumor Agents: Experimental Study on Lewis Lung Carcinoma Model |
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