Glycolysis Inhibitors Monoiodoacetate and 2-Deoxyglucose as Antitumor Agents: Experimental Study on Lewis Lung Carcinoma Model

Glycolysis Inhibitors Monoiodoacetate and 2-Deoxyglucose as Antitumor Agents: Experimental Study on Lewis Lung Carcinoma Model

Antitumor effects of glycolysis inhibitors monoiodoacetate and 2-deoxyglucose were studied on Lewis lung carcinoma model. Monoiodoacetate exhibited antitumor and antimetastatic activities, being not inferior of methotrexate (reference drug); however, the preparation also demonstrated high systemic t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Bulletin of experimental biology and medicine 2018-09, Vol.165 (5), p.695-697
Hauptverfasser: Korshunov, D. A., Klimov, I. A., Ivanov, V. V., Kondakova, I. V.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antineoplastic Agents - pharmacology
Antitumor activity
Antitumor agents
Biomedical and Life Sciences
Biomedicine
Carcinoma
Carcinoma, Lewis Lung - drug therapy
Carcinoma, Lewis Lung - metabolism
Carcinoma, Lewis Lung - pathology
Cell Biology
Deoxyglucose
Deoxyglucose - pharmacology
Glucose metabolism
Glycolysis
Glycolysis - drug effects
Internal Medicine
Iodoacetic Acid - pharmacology
Laboratory Medicine
Lung cancer
Lung carcinoma
Lung Neoplasms - drug therapy
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Lymphatic Metastasis - prevention & control
Male
Methotrexate
Methotrexate - pharmacology
Mice
Mice, Inbred C57BL
Pathology
Toxicity
Treatment Outcome
Tumor Burden - drug effects
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Antitumor effects of glycolysis inhibitors monoiodoacetate and 2-deoxyglucose were studied on Lewis lung carcinoma model. Monoiodoacetate exhibited antitumor and antimetastatic activities, being not inferior of methotrexate (reference drug); however, the preparation also demonstrated high systemic toxicity. 2-Deoxyglucose exhibited only antitumor effect, while its antimetastatic activity did not differ from the result in the group without treatment.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4244-1