Antidiabetic Activity of Afobazole in Wistar Rats

Using the streptozotocin model of type 2 diabetes mellitus in Wistar rats, we compared antidiabetic activity of anxiolytic Afobazole with that of metformin. Afobazole in a dose of 10 mg/kg reduced streptozotocin-induced hyperglycemia and polyphagia and prevented accumulation of malonic dialdehyde, b...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2018-09, Vol.165 (5), p.649-652
Hauptverfasser: Ostrovskaya, R. U., Ivanov, S. V., Voronin, M. V., Ozerova, I. V., Zolotov, N. N., Seredenin, S. B.
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Sprache:eng
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Zusammenfassung:Using the streptozotocin model of type 2 diabetes mellitus in Wistar rats, we compared antidiabetic activity of anxiolytic Afobazole with that of metformin. Afobazole in a dose of 10 mg/kg reduced streptozotocin-induced hyperglycemia and polyphagia and prevented accumulation of malonic dialdehyde, being not inferior to metformin in a dose of 300 mg/kg, and was even more effective than metformin in body weight recovery, elimination of polydipsia, and preservation of these effects after treatment withdrawal.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4233-4