Intermittent Treatment for the Prevention of Malaria during Pregnancy in Benin: A Randomized, Open-Label Equivalence Trial Comparing Sulfadoxine-Pyrimethamine with Mefloquine

Intermittent Treatment for the Prevention of Malaria during Pregnancy in Benin: A Randomized, Open-Label Equivalence Trial Comparing Sulfadoxine-Pyrimethamine with Mefloquine

BackgroundIn the context of the increasing resistance to sulfadoxine-pyrimethamine (SP), we evaluated the efficacy of mefloquine (MQ) for intermittent preventive treatment during pregnancy (IPTp) MethodsA multicenter, open-label equivalence trial was conducted in Benin from July 2005 through April 2...

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Veröffentlicht in:The Journal of infectious diseases 2009-09, Vol.200 (6), p.991-1001
Hauptverfasser: Briand, Valérie, Bottero, Julie, Noël, Harold, Masse, Virginie, Cordel, Hugues, Guerra, José, Kossou, Hortense, Fayomi, Benjamin, Ayemonna, Paul, Fievet, Nadine, Massougbodji, Achille, Cot, Michel
Format: Artikel
Sprache:eng
Schlagworte:
Abnormalities, Drug-Induced
Abortion, Spontaneous - chemically induced
Adult
Anemia
Antimalarials
Antimalarials - adverse effects
Antimalarials - therapeutic use
Birth weight
Blood
Dosage
Drug Combinations
Female
Humans
Infant
Infant, Newborn
Infants
Malaria
Malaria - prevention & control
Mefloquine - adverse effects
Mefloquine - therapeutic use
PARASITES
Pregnancy
Pregnancy Complications, Parasitic - prevention & control
Pyrimethamine - adverse effects
Pyrimethamine - therapeutic use
Single-Blind Method
Stillbirth
Sulfadoxine - adverse effects
Sulfadoxine - therapeutic use
Women
Young Adult
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Zusammenfassung:BackgroundIn the context of the increasing resistance to sulfadoxine-pyrimethamine (SP), we evaluated the efficacy of mefloquine (MQ) for intermittent preventive treatment during pregnancy (IPTp) MethodsA multicenter, open-label equivalence trial was conducted in Benin from July 2005 through April 2008. Women of all gravidities were randomized to receive SP (1500 mg of sulfadoxine and 75 mg of pyrimethamine) or 15 mg/kg MQ in a single intake twice during pregnancy. The primary end point was the proportion of low–birth-weight (LBW) infants (body weight,
ISSN:0022-1899
1537-6613
DOI:10.1086/605474