Synthesis and evaluation of antibacterial and antibiofilm activities of pyridin-2-yl hexanoate

Synthesized Pyridin-2-yl hexanoate was screened for its antibacterial and antibiofilm activities using the broth microdilution method and XTT assay respectively. The obtained results revealed that synthesized molecule inhibited the growth of pathogenic bacteria (MICs value ranged from 80 to 640 μg ml−1). Moreover, it induced a strong antibiofilm effect against Gram positive cocci (BIC50 was 366, 378 and 412 μg ml−1 for Streptococcus mutans ATCC 25175, Streptococcus salivarius ATCC 13419 and Streptococcus oralis ATCC 6249 respectively). Basis on these results, pyridin-2-yl hexanoate may be considered as effective compound with antibacterial and antibiofilm activities. •Heterocycles are of importance for making new pharmacological compounds.•Pyridin-2-yl hexanoate is more active on the cocci than the bacilli.•Synthetised pyridin-2-yl hexanoate may be used as a novel strategy to control oral pathogen and eradicate microbial biofilm.