Biodegradable poly(ɛ-caprolactone)–poly(ethylene glycol) copolymers as drug delivery system

Poly(ɛ-caprolactone)–poly(ethylene glycol) (PCL–PEG) copolymers are important synthetic biomedical materials with amphiphilicity, controlled biodegradability, and great biocompatibility. They have great potential application in the fields of nanotechnology, tissue engineering, pharmaceutics, and med...

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Veröffentlicht in:	International journal of pharmaceutics 2009-10, Vol.381 (1), p.1-18
Hauptverfasser:	Wei, XiaWei, Gong, ChangYang, Gou, MaLing, Fu, ShaoZhi, Guo, QingFa, Shi, Shuai, Luo, Feng, Guo, Gang, Qiu, LiYan, Qian, ZhiYong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatible Materials - chemistry Biodegradation, Environmental Biological and medical sciences Drug Carriers Ethylene Glycols - chemical synthesis Ethylene Glycols - chemistry Ethylene Glycols - toxicity General pharmacology Humans Hydrogels Hydrogels - chemistry Medical sciences Microparticles Nanoparticles Nanoparticles - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly(ɛ-caprolactone)–poly(ethylene glycol) copolymer Polyesters - chemical synthesis Polyesters - chemistry Polyesters - toxicity Polymeric drug delivery systems
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Beschreibung
Zusammenfassung:	Poly(ɛ-caprolactone)–poly(ethylene glycol) (PCL–PEG) copolymers are important synthetic biomedical materials with amphiphilicity, controlled biodegradability, and great biocompatibility. They have great potential application in the fields of nanotechnology, tissue engineering, pharmaceutics, and medicinal chemistry. This review introduced several aspects of PCL–PEG copolymers, including synthetic chemistry, PCL–PEG micro/nanoparticles, PCL–PEG hydrogels, and physicochemical and toxicological properties.
ISSN:	0378-5173 1873-3476
DOI:	10.1016/j.ijpharm.2009.07.033