Non-invasive detection of hippocampal sclerosis: correlation between metabolite alterations detected by 1H-MRS and neuropathology

Non-invasive detection of hippocampal sclerosis: correlation between metabolite alterations detected by 1H-MRS and neuropathology

We assessed 1H‐MRS as a screening tool for detection of hippocampal sclerosis in patients with temporal lobe epilepsy (TLE). 1H‐MRS was carried out in the hippocampus of 23 patients with unilateral TLE. Metabolite alterations detected by 1H‐MRS correlated with degree of segmental neuronal cell loss...

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Veröffentlicht in:NMR in biomedicine 2008-07, Vol.21 (6), p.545-552
Hauptverfasser: Hammen, Thilo, Hildebrandt, Michelle, Stadlbauer, Andreas, Doelken, Marc, Engelhorn, Tobias, Kerling, Frank, Kasper, Burkhard, Romstoeck, Johann, Ganslandt, Oliver, Nimsky, Christopher, Blumcke, Ingmar, Doerfler, Arndt, Stefan, Hermann
Format: Artikel
Sprache:eng
Schlagworte:
1H-MRS
astrogliosis
glial fibrillary acid protein (GFAP)
hippocampal sclerosis
neuronal cell count
temporal lobe epilepsy (TLE)
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Zusammenfassung:We assessed 1H‐MRS as a screening tool for detection of hippocampal sclerosis in patients with temporal lobe epilepsy (TLE). 1H‐MRS was carried out in the hippocampus of 23 patients with unilateral TLE. Metabolite alterations detected by 1H‐MRS correlated with degree of segmental neuronal cell loss and amount of astrogliosis. Positive correlation was found between total N‐Acetylaspartate (tNAA) reduction and neuronal density in hippocampal CA1 (P 
ISSN:0952-3480
1099-1492
DOI:10.1002/nbm.1222