Expanded TCR V beta subsets of CD8 super(+) T-cells in late-onset myasthenia gravis: Novel parallels with thymoma patients

Expanded TCR V beta subsets of CD8 super(+) T-cells in late-onset myasthenia gravis: Novel parallels with thymoma patients

Little is known about pathogenesis - and especially about involvement of CD8 super(+) T-cells - in late-onset myasthenia gravis (LOMG). Remarkably, outstanding CD8 super(+) TCRV beta -subset expansions were found in 64% and 72% of recent onset LOMG or thymoma-associated MG (vs. 16% with early-onset...

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Veröffentlicht in:Journal of neuroimmunology 2009-11, Vol.216 (1-2), p.85-91
Hauptverfasser: Tackenberg, B, Schlegel, K, Happel, M, Eienbroker, C, Gellert, K, Oertel, W H, Meager, A, Willcox, N, Sommer, N
Format: Artikel
Sprache:eng
Schlagworte:
Cytomegalovirus
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Zusammenfassung:Little is known about pathogenesis - and especially about involvement of CD8 super(+) T-cells - in late-onset myasthenia gravis (LOMG). Remarkably, outstanding CD8 super(+) TCRV beta -subset expansions were found in 64% and 72% of recent onset LOMG or thymoma-associated MG (vs. 16% with early-onset MG (p
ISSN:0165-5728
DOI:10.1016/j.jneuroim.2009.08.018