Reciprocal changes of H3K27ac and H3K27me3 at the promoter regions of the critical genes for endometrial decidualization
Decidualization is essential for embryo implantation and placental development. We aimed to obtain transcriptome and epigenome profiles for primary endometrial stromal cells (ESCs) and decidualized cells. ESCs isolated from human endometrial tissues remained untreated (D0), or decidualized for 4 day...
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| Veröffentlicht in: | Epigenomics 2018-09, Vol.10 (9), p.1243-1257 |
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| creator | Katoh, Noriko Kuroda, Keiji Tomikawa, Junko Ogata-Kawata, Hiroko Ozaki, Rie Ochiai, Asako Kitade, Mari Takeda, Satoru Nakabayashi, Kazuhiko Hata, Kenichiro |
| description | Decidualization is essential for embryo implantation and placental development. We aimed to obtain transcriptome and epigenome profiles for primary endometrial stromal cells (ESCs) and
decidualized cells.
ESCs isolated from human endometrial tissues remained untreated (D0), or decidualized for 4 days (D4) and 8 days (D8) in the presence of 8-bromo-cAMP and progesterone.
Among the epigenetic modifications examined (DNA methylation, H3K27ac, H3K9me3 and H3K27me3), the H3K27ac patterns changed most dramatically, with a moderate correlation with gene expression changes, upon decidualization. Subsets of up- and down-regulated genes upon decidualization were associated with reciprocal changes of H3K27ac and H3K27me3 modifications at their promoter region, and were enriched with genes essential for decidualization such as
,
,
and
.
Our dataset is useful to further elucidate the molecular mechanisms underlying decidualization. |
| doi_str_mv | 10.2217/epi-2018-0006 |
| format | Article |
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decidualized cells.
ESCs isolated from human endometrial tissues remained untreated (D0), or decidualized for 4 days (D4) and 8 days (D8) in the presence of 8-bromo-cAMP and progesterone.
Among the epigenetic modifications examined (DNA methylation, H3K27ac, H3K9me3 and H3K27me3), the H3K27ac patterns changed most dramatically, with a moderate correlation with gene expression changes, upon decidualization. Subsets of up- and down-regulated genes upon decidualization were associated with reciprocal changes of H3K27ac and H3K27me3 modifications at their promoter region, and were enriched with genes essential for decidualization such as
,
,
and
.
Our dataset is useful to further elucidate the molecular mechanisms underlying decidualization.</description><identifier>ISSN: 1750-1911</identifier><identifier>EISSN: 1750-192X</identifier><identifier>DOI: 10.2217/epi-2018-0006</identifier><identifier>PMID: 30212243</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Cell culture ; Charcoal ; decidualization ; Deoxyribonucleic acid ; DNA ; DNA methylation ; Embryos ; Endometriosis ; Endometrium ; Epigenetics ; epigenome ; Gene expression ; Genes ; Genomes ; Genomics ; histone modifications ; Hormones ; Implantation ; In vitro methods and tests ; Molecular modelling ; Placenta ; Progesterone ; Stromal cells ; Wnt protein</subject><ispartof>Epigenomics, 2018-09, Vol.10 (9), p.1243-1257</ispartof><rights>2018 Future Medicine Ltd</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-ca07bcbb0d603f5d2a3634005b44eec3da551943d69a0131562b9bc8194c6f593</citedby><cites>FETCH-LOGICAL-c505t-ca07bcbb0d603f5d2a3634005b44eec3da551943d69a0131562b9bc8194c6f593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30212243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katoh, Noriko</creatorcontrib><creatorcontrib>Kuroda, Keiji</creatorcontrib><creatorcontrib>Tomikawa, Junko</creatorcontrib><creatorcontrib>Ogata-Kawata, Hiroko</creatorcontrib><creatorcontrib>Ozaki, Rie</creatorcontrib><creatorcontrib>Ochiai, Asako</creatorcontrib><creatorcontrib>Kitade, Mari</creatorcontrib><creatorcontrib>Takeda, Satoru</creatorcontrib><creatorcontrib>Nakabayashi, Kazuhiko</creatorcontrib><creatorcontrib>Hata, Kenichiro</creatorcontrib><title>Reciprocal changes of H3K27ac and H3K27me3 at the promoter regions of the critical genes for endometrial decidualization</title><title>Epigenomics</title><addtitle>Epigenomics</addtitle><description>Decidualization is essential for embryo implantation and placental development. We aimed to obtain transcriptome and epigenome profiles for primary endometrial stromal cells (ESCs) and
decidualized cells.
ESCs isolated from human endometrial tissues remained untreated (D0), or decidualized for 4 days (D4) and 8 days (D8) in the presence of 8-bromo-cAMP and progesterone.
Among the epigenetic modifications examined (DNA methylation, H3K27ac, H3K9me3 and H3K27me3), the H3K27ac patterns changed most dramatically, with a moderate correlation with gene expression changes, upon decidualization. Subsets of up- and down-regulated genes upon decidualization were associated with reciprocal changes of H3K27ac and H3K27me3 modifications at their promoter region, and were enriched with genes essential for decidualization such as
,
,
and
.
Our dataset is useful to further elucidate the molecular mechanisms underlying decidualization.</description><subject>Cell culture</subject><subject>Charcoal</subject><subject>decidualization</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>Embryos</subject><subject>Endometriosis</subject><subject>Endometrium</subject><subject>Epigenetics</subject><subject>epigenome</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genomes</subject><subject>Genomics</subject><subject>histone modifications</subject><subject>Hormones</subject><subject>Implantation</subject><subject>In vitro methods and tests</subject><subject>Molecular modelling</subject><subject>Placenta</subject><subject>Progesterone</subject><subject>Stromal cells</subject><subject>Wnt protein</subject><issn>1750-1911</issn><issn>1750-192X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kcFrFjEQxYMottQevUrAi5etk2ST3T1KsVYsCKLgLWST2a8pu8lnkoXqX2_WrT0InjJ5_ObNMI-QlwwuOGfdWzz6hgPrGwBQT8gp6yQ0bODfnz7WjJ2Q85zvKgGC94Niz8mJAM44b8Upuf-C1h9TtGam9taEA2YaJ3otPvHOWGqC2-sFBTWFlluklV5iwUQTHnwMf_hNt8kXv_kcMFSXKSaKwcUFS_JVdXWQW83sf5lS216QZ5OZM54_vGfk29X7r5fXzc3nDx8v3900VoIsjTXQjXYcwSkQk3TcCCVaADm2LaIVzkjJhlY4NRhggknFx2G0fdWsmuQgzsib3beu_WPFXPTis8V5NgHjmjVnUAf10KmKvv4HvYtrCnU7Xa-tJOv6dqOanbIp5pxw0sfkF5N-agYb1-mait5S0VsqlX_14LqOC7pH-m8GFRh2YFrLmjBbj8Gi3n-1w1sf8D_mvwEGrpnx</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Katoh, Noriko</creator><creator>Kuroda, Keiji</creator><creator>Tomikawa, Junko</creator><creator>Ogata-Kawata, Hiroko</creator><creator>Ozaki, Rie</creator><creator>Ochiai, Asako</creator><creator>Kitade, Mari</creator><creator>Takeda, Satoru</creator><creator>Nakabayashi, Kazuhiko</creator><creator>Hata, Kenichiro</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180901</creationdate><title>Reciprocal changes of H3K27ac and H3K27me3 at the promoter regions of the critical genes for endometrial decidualization</title><author>Katoh, Noriko ; Kuroda, Keiji ; Tomikawa, Junko ; Ogata-Kawata, Hiroko ; Ozaki, Rie ; Ochiai, Asako ; Kitade, Mari ; Takeda, Satoru ; Nakabayashi, Kazuhiko ; Hata, Kenichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-ca07bcbb0d603f5d2a3634005b44eec3da551943d69a0131562b9bc8194c6f593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cell culture</topic><topic>Charcoal</topic><topic>decidualization</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>Embryos</topic><topic>Endometriosis</topic><topic>Endometrium</topic><topic>Epigenetics</topic><topic>epigenome</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genomes</topic><topic>Genomics</topic><topic>histone modifications</topic><topic>Hormones</topic><topic>Implantation</topic><topic>In vitro methods and tests</topic><topic>Molecular modelling</topic><topic>Placenta</topic><topic>Progesterone</topic><topic>Stromal cells</topic><topic>Wnt protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katoh, Noriko</creatorcontrib><creatorcontrib>Kuroda, Keiji</creatorcontrib><creatorcontrib>Tomikawa, Junko</creatorcontrib><creatorcontrib>Ogata-Kawata, Hiroko</creatorcontrib><creatorcontrib>Ozaki, Rie</creatorcontrib><creatorcontrib>Ochiai, Asako</creatorcontrib><creatorcontrib>Kitade, Mari</creatorcontrib><creatorcontrib>Takeda, Satoru</creatorcontrib><creatorcontrib>Nakabayashi, Kazuhiko</creatorcontrib><creatorcontrib>Hata, Kenichiro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Epigenomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katoh, Noriko</au><au>Kuroda, Keiji</au><au>Tomikawa, Junko</au><au>Ogata-Kawata, Hiroko</au><au>Ozaki, Rie</au><au>Ochiai, Asako</au><au>Kitade, Mari</au><au>Takeda, Satoru</au><au>Nakabayashi, Kazuhiko</au><au>Hata, Kenichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reciprocal changes of H3K27ac and H3K27me3 at the promoter regions of the critical genes for endometrial decidualization</atitle><jtitle>Epigenomics</jtitle><addtitle>Epigenomics</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>10</volume><issue>9</issue><spage>1243</spage><epage>1257</epage><pages>1243-1257</pages><issn>1750-1911</issn><eissn>1750-192X</eissn><abstract>Decidualization is essential for embryo implantation and placental development. We aimed to obtain transcriptome and epigenome profiles for primary endometrial stromal cells (ESCs) and
decidualized cells.
ESCs isolated from human endometrial tissues remained untreated (D0), or decidualized for 4 days (D4) and 8 days (D8) in the presence of 8-bromo-cAMP and progesterone.
Among the epigenetic modifications examined (DNA methylation, H3K27ac, H3K9me3 and H3K27me3), the H3K27ac patterns changed most dramatically, with a moderate correlation with gene expression changes, upon decidualization. Subsets of up- and down-regulated genes upon decidualization were associated with reciprocal changes of H3K27ac and H3K27me3 modifications at their promoter region, and were enriched with genes essential for decidualization such as
,
,
and
.
Our dataset is useful to further elucidate the molecular mechanisms underlying decidualization.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>30212243</pmid><doi>10.2217/epi-2018-0006</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Cell culture Charcoal decidualization Deoxyribonucleic acid DNA DNA methylation Embryos Endometriosis Endometrium Epigenetics epigenome Gene expression Genes Genomes Genomics histone modifications Hormones Implantation In vitro methods and tests Molecular modelling Placenta Progesterone Stromal cells Wnt protein |
| title | Reciprocal changes of H3K27ac and H3K27me3 at the promoter regions of the critical genes for endometrial decidualization |
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