The effects of intra-rectal and intra-peritoneal application of Origanum onites L. essential oil on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat

The aim of the present study is to investigate the treatment efficiency of intra-rectal (IR) and intra-peritoneal (IP) application of Origanum onites essential oil (OOEO), which is a well-known antioxidant, in the colitis model induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) and ethanol (E) in...

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Veröffentlicht in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2008-04, Vol.59 (6), p.399-408
Hauptverfasser:	Dundar, Emine, Olgun, Esra Gurlek, Isiksoy, Serap, Kurkcuoglu, Mine, Baser, K. Husnu Can, Bal, Cengiz
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Trinitrobenzenesulfonic acid-induced colitis Administration, Rectal Animals Antioxidants - administration & dosage Antioxidants - isolation & purification Antioxidants - therapeutic use Biological and medical sciences Colitis - chemically induced Colitis - drug therapy Colitis - pathology Colitis, Ulcerative - chemically induced Colitis, Ulcerative - drug therapy Colitis, Ulcerative - pathology Colon - drug effects Colon - metabolism Colon - pathology Dexamethasone - therapeutic use Disease Models, Animal Ethanol - toxicity Gas Chromatography-Mass Spectrometry Gastroenterology. Liver. Pancreas. Abdomen Immunohistochemistry Injections, Intraperitoneal Intercellular Adhesion Molecule-1 - metabolism Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Investigative techniques, diagnostic techniques (general aspects) Medical sciences Oils, Volatile - administration & dosage Oils, Volatile - isolation & purification Oils, Volatile - therapeutic use Origanum Origanum - chemistry Origanum onites Other diseases. Semiology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Peroxidase - metabolism Rats Rats, Sprague-Dawley Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Treatment of inflammatory bowel disease Trinitrobenzenesulfonic Acid - toxicity
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Zusammenfassung:	The aim of the present study is to investigate the treatment efficiency of intra-rectal (IR) and intra-peritoneal (IP) application of Origanum onites essential oil (OOEO), which is a well-known antioxidant, in the colitis model induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) and ethanol (E) in comparison with dexamethasone therapy through the morphologic damage score. Monoclonal antibodies against intercellular adhesion molecule-1 (ICAM-1, CD54), anti-rat granulocytes, and myeloperoxidase (MPO), were also investigated immunohistochemically. There was a significant difference in terms of ulceration, mucus cell depletion, inflammatory cell infiltration, vascular dilatation ( p
ISSN:	0940-2993 1618-1433
DOI:	10.1016/j.etp.2007.11.009