Neurocognitive functioning and HAART in HIV and hepatitis C virus co-infection

This study examined the effects of HAART on neurocognitive functioning in persons with hepatitis C virus (HCV) and HIV co-infection. A prospective study examining neurocognitive performance before and after HAART initiation. Participant groups included a mono-infected group (45 HIV+/HCV- participant...

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Veröffentlicht in:AIDS (London) 2006-08, Vol.20 (12), p.1591-1595
Hauptverfasser: PARSONS, Thomas D, TUCKER, Karen A, HALL, Colin D, ROBERTSON, Wendy T, ERON, Joseph J, FRIED, Michael W, ROBERTSON, Kevin R
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Sprache:eng
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Zusammenfassung:This study examined the effects of HAART on neurocognitive functioning in persons with hepatitis C virus (HCV) and HIV co-infection. A prospective study examining neurocognitive performance before and after HAART initiation. Participant groups included a mono-infected group (45 HIV+/HCV- participants) and a co-infected group (20 HIV+/HCV+ participants). A neuropsychological battery (attention/concentration, psychomotor speed, executive functioning, verbal memory, visual memory, fine motor, and gross motor functioning) was used to evaluate all participants. After 6 months of HAART, 31 HIV+ mono-infected and 13 HCV+/HIV+ co-infected participants were reevaluated. Neurocognitive functioning by domain revealed significantly worse performance in the co-infected group when compared to the monoinfected group on domains of visual memory and fine motor functioning. Assessment of neurocognitive functioning after antiretroviral therapy revealed that the co-infected group was no longer performing worse than the monoinfected group. The findings of the current study suggest that persons with HCV+/HIV+ co-infection may have greater neurocognitive declines than persons with HIV infection alone. HCV+/HIV+ co-infection may accelerate the progression of HIV related neurocognitive decline.
ISSN:0269-9370
1473-5571
DOI:10.1097/01.aids.0000238404.16121.47