Outbreak of Hypervirulent Multidrug-resistant Klebsiella variicola Causing High Mortality in Neonates in Bangladesh

Abstract We report a clonal outbreak of multidrug-resistant (MDR) Klebsiella variicola (sequence type [ST] 771) in a Bangladeshi neonatal unit from October 2016 to January 2017, associated with high mortality (54.5%). During the outbreak, K. variicola ST771 acquired an MDR plasmid harboring blaNDM-1...

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Veröffentlicht in:	Clinical infectious diseases 2019-03, Vol.68 (7), p.1225-1227
Hauptverfasser:	Farzana, Refath, Jones, Lim S, Rahman, Md Anisur, Andrey, Diego O, Sands, Kirsty, Portal, Edward, Watkins, W John, Pervin, Monira, Banerjee, Manisha, Walsh, Timothy R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amikacin - therapeutic use Anti-Bacterial Agents - therapeutic use Bangladesh - epidemiology beta-Lactamases - genetics Ceftriaxone - therapeutic use Disease Outbreaks Drug Resistance, Multiple, Bacterial Female Genotype Humans Infant, Newborn Klebsiella - classification Klebsiella - drug effects Klebsiella - genetics Klebsiella - isolation & purification Klebsiella Infections - epidemiology Klebsiella Infections - microbiology Klebsiella Infections - mortality Male Plasmids - analysis Survival Analysis
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Zusammenfassung:	Abstract We report a clonal outbreak of multidrug-resistant (MDR) Klebsiella variicola (sequence type [ST] 771) in a Bangladeshi neonatal unit from October 2016 to January 2017, associated with high mortality (54.5%). During the outbreak, K. variicola ST771 acquired an MDR plasmid harboring blaNDM-1, linked to high exposure to ceftriaxone and amikacin.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/ciy778