No evidence for a major effect of three common polymorphisms of the GPx1, MnSOD, and CAT genes on PCOS susceptibility

Aim Polycystic ovary syndrome (PCOS) is one of the prevalent endocrine‐metabolic disorders. It is proposed that oxidative stress contributes to PCOS susceptibility and its metabolic associations. The current study aimed to investigate the influence of GPx1 (rs1050450), MnSOD (rs4880), and Catalase (rs1001179) variants with PCOS susceptibility, for the first time. Methods In a case‐control study, 350 Kurdish female volunteers (175 PCOS patients and 175 healthy controls) from Western Iran were studied. Genotyping for GPx1 and MnSOD were done using PCR‐RFLP and for CAT the allele‐specific PCR method was used. Results The percentage of patients suffering from hirsutism, acne, and acanthosis among patients with PCOS were 44.6%, 30.3%, and 14.9%, respectively. Distribution of alleles among patients suffering from PCOS versus healthy women was ‘Pro’ (69.1% vs 68.8%) and ‘Leu’ (31.4% vs 31.2%) for Gpx1, ‘Ala’ (61.43% vs 56.57%) and ‘Val’ (38.57% vs 43.43%) for MnSOD, and ‘C’ (83.43% vs 84.57%) and ‘T’ (16.57% vs 15.43%) for CAT. Conclusion GPx1 (rs1050450), MnSOD (rs4880), and CAT (rs1001179) variants might not be a risk factor for PCOS. GPx1 (rs1050450), MnSOD (rs4880), and CAT (rs1001179) variants might not be a risk factor for PCOS.